达沙替尼治疗CML患者分离性中枢神经细胞危象1例

Journal of leukemia (Los Angeles, Calif.) Pub Date : 2016-07-13 DOI:10.4172/2329-6917.1000212

R. Alblooshi, D. Vergidis, J. Lipton

{"title":"达沙替尼治疗CML患者分离性中枢神经细胞危象1例","authors":"R. Alblooshi, D. Vergidis, J. Lipton","doi":"10.4172/2329-6917.1000212","DOIUrl":null,"url":null,"abstract":"We report a case of a young male with chronic phase CML who despite achieving an excellent response to dasatinib therapy, developed isolated CNS blast crisis even though this tyrosine kinase inhibitor is the only one reported to cross the blood brain barrier.","PeriodicalId":90223,"journal":{"name":"Journal of leukemia (Los Angeles, Calif.)","volume":"4 1","pages":"1-2"},"PeriodicalIF":0.0000,"publicationDate":"2016-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"5","resultStr":"{\"title\":\"Isolated CNS Blast Crisis of CML in A Patient on Dasatinib Therapy\",\"authors\":\"R. Alblooshi, D. Vergidis, J. Lipton\",\"doi\":\"10.4172/2329-6917.1000212\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"We report a case of a young male with chronic phase CML who despite achieving an excellent response to dasatinib therapy, developed isolated CNS blast crisis even though this tyrosine kinase inhibitor is the only one reported to cross the blood brain barrier.\",\"PeriodicalId\":90223,\"journal\":{\"name\":\"Journal of leukemia (Los Angeles, Calif.)\",\"volume\":\"4 1\",\"pages\":\"1-2\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2016-07-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"5\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of leukemia (Los Angeles, Calif.)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4172/2329-6917.1000212\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of leukemia (Los Angeles, Calif.)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4172/2329-6917.1000212","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 5

摘要

我们报告一例患有慢性粒细胞白血病的年轻男性，尽管对达沙替尼治疗取得了极好的反应，但尽管这种酪氨酸激酶抑制剂是唯一一种据报道可以穿过血脑屏障的药物，但仍发生了孤立的中枢神经系统母细胞危像。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Isolated CNS Blast Crisis of CML in A Patient on Dasatinib Therapy

We report a case of a young male with chronic phase CML who despite achieving an excellent response to dasatinib therapy, developed isolated CNS blast crisis even though this tyrosine kinase inhibitor is the only one reported to cross the blood brain barrier.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Journal of leukemia (Los Angeles, Calif.)

自引率

0.00%

发文量