Sufeng Ruan, SuFei Yang, Jinrong Li, F. Xiong, D. Qie, You Lu, Zhanghui Tang, Fan Yang
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引用次数: 0
摘要
缺铁和缺铁性贫血在低收入国家普遍存在，尤其是在早产儿中。Hepcidin是铁代谢的关键调节因子，这为早产儿ID的诊断提供了新的解决方案。目的探讨早产儿铁代谢与hepcidin的关系。材料与方法本研究纳入81例28+1 ~ 36+6岁的早产儿，在校正胎龄6个月时接受铁状态指标和hepcidin检测。根据铁状态指标将早产儿分为两组:ID组和无ID组。结果有ID早产儿血清hepcidin低于无ID早产儿(log10hepcidin, 1.18±0.44 vs 1.49±0.37,p = 0.002)。采用单变量线性回归模型探讨hepcidin与其他铁代谢指标的相关性。相关分析显示hepcidin水平与铁蛋白水平呈显著正相关(p < 0.001)。结论shepcidin可作为一种有效的铁储存指标，是早期诊断早产儿ID的一种有前景的指标。
Iron deficiency (ID) and ID anemia are widespread in low-income countries, particularly among preterm infants. Hepcidin is a key regulator of iron metabolism, which offers the possibility of new solutions to diagnose ID in premature infants.
Objective
To explore the relationship between iron metabolism and hepcidin in premature infants.
Materials and methods
The study involved 81 preterm infants between 28+1 and 36+6 who underwent iron status indicators and hepcidin testing at 6 months of corrected gestational age. The preterm infants were divided into two groups based on iron status indicators: ID and no ID.
Results
Serum hepcidin was lower for premature infants with ID compared to those without ID (log10hepcidin, 1.18 ± 0.44 vs 1.49 ± 0.37, p = 0.002). A single-variate linear regression model was used to explore the correlation between hepcidin and other indicators of iron metabolism. A strongly positive relationship was observed between hepcidin levels and ferritin levels (p < 0.001) in the correlation analysis.
Conclusions
Hepcidin can be used as an efficient indicator of iron storage and a promising indicator for the early diagnosis of ID in premature infants.
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