药物发现中的天然产物:满足人类和兽医使用的新型抗菌素的紧迫性

IF 0.7 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
M. V. Dias-Souza, Arthur Azevedo Perpétuo, Gabriel Souza dos Santos, Luiz Felipe Carreiro Machado, R. D. dos Santos
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引用次数: 1

摘要

微生物耐药性日益增强以及制药公司对开发新的抗微生物药物缺乏兴趣的情况危及传染病治疗的现在和未来。已经探索了不同的方法,如抗菌肽和CRISP-R来管理这种情况,然而,它们有重要的局限性,如它们的高成本。天然产物包含复杂的分子结构,细菌耐药性的报道很少。它们提供了特定和/或非特定的作用机制,可以探索这些机制,以提供安全有效的传染病管理。在这篇综述中,我们评估了植物提取物对治疗人类和动物传染病的益处,并将数据用于临床和实验目的。细菌对抗菌素耐药的机制也进行了讨论。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Natural products in drug discovery: meeting the urgency for new antimicrobials for human and veterinary use
The scenario of growing microbial resistance and of lack of interest of pharmaceutical companies in developing new antimicrobial drugs jeopardizes the present and the future of the treatment of infectious diseases. Different approaches such as antimicrobial peptides and CRISP-R have been explored to manage this situation, however, they have important limitations such as their high cost. Natural products comprise complex molecular structures for which reports of bacterial resistance are rare. They present specific and/or unspecific mechanisms of action that can be explored to provide safe and effective management of infectious diseases. In this review we assessed phytoextracts with evidence of their benefits for treating infectious diseases in humans and animals, towards the use of data for clinical and experimental purposes. Mechanisms of bacterial resistance to antimicrobials are also discussed.
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来源期刊
AIMS Molecular Science
AIMS Molecular Science BIOCHEMISTRY & MOLECULAR BIOLOGY-
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