疣患者血清白细胞介素19水平的测定

IF 0.7 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
R. Marie, Aya Mohamed kamal Lasheen, H. Nashaat, M. Atwa
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引用次数: 1

摘要

背景:疣是由人乳头瘤病毒(HPV)引起的病毒性皮肤感染,表现为皮肤表面的疣状生长。细胞介导的免疫反应被认为在HPV清除中起关键作用。当辅助性t - 1和辅助性t - 2免疫反应不平衡时,病毒载量和病变数量增加。白介素(IL)-19是白介素- 10细胞因子家族的一种细胞因子,与IL-20、IL-22、IL-24组成一个亚家族。IL-19主要由活化的单核细胞产生,少量由b细胞、角化细胞和胎膜产生。IL-19被发现将t细胞的成熟从促炎t -辅助1细胞转向抗炎t -辅助2细胞。它诱导T细胞产生IL-4和IL-13,并诱导单核细胞凋亡。目的:本研究旨在测定疣患者血清IL-19水平与健康对照组的比较,并探讨IL-19水平与疣的数量、大小及临床类型的相关性。方法:选取50例疣患者和50例对照组。采用酶联免疫吸附法测定血清IL-19浓度。结果:疣患者血清白细胞介素-19水平明显低于对照组(P < 0.003)。血清IL-19水平与疣数呈显著正相关(P = 0.027)。结论:疣患者血清IL-19水平明显降低,这种低水平可能对HPV有效的细胞介导免疫应答至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Assessment of serum interleukin 19 level in patients with warts
Background: Warts are viral cutaneous infections caused by human papilloma virus (HPV), presented by verrucous growth over the skin surface. The cell mediated immune response is considered to play a crucial role in HPV clearance. The viral load and number of lesions increase when there is an imbalance between the T-helper 1 and T-helper 2 immune responses. Interleukin (IL)-19 is a cytokine that belongs to interleukin 10 cytokines family and constitutes a sub-family with IL-20, IL-22 and IL-24. IL-19 is mainly produced by activated monocytes and to a lesser extent by B-cells, keratinocytes and fetal membranes. IL-19 was found to shift T-cell maturation away from the pro-inflammatory T-helper 1 cells toward the anti-inflammatory T-helper 2 cells. It induces IL-4 and IL-13 production in T cells and apoptosis in monocytes. Aim: This study aimed to measure serum level of IL-19 in patients with warts compared to healthy controls and to find out the correlation between this level and number, size and clinical types of warts. Methods: The study included 50 patients with warts and 50 control subjects. Serum concentration of IL-19 was measured by enzyme-linked immune sorbent assay. Results: Interleukin-19 serum level was significantly lower in patients with warts than in controls (P < 0.003). Moreover, there was a significant positive correlation between IL-19 serum level and the number of warts (P = 0.027). Conclusion: Serum level of IL-19 was significantly lower in patients with warts, and this low level might be crucial for an effective cell mediated immunological response to HPV.
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来源期刊
AIMS Molecular Science
AIMS Molecular Science BIOCHEMISTRY & MOLECULAR BIOLOGY-
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