阿尔茨海默病:脑肾素-血管紧张素系统、雌二醇和葡萄糖转运蛋白-4 (GLUT-4)之间是否存在关系?

IF 0.7 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
M. P. Carrera-González, M. J. Ramírez-Expósito, Carmen Guerrero-González, J. Martínez-Martos
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引用次数: 0

摘要

与人口持续老龄化更相关的疾病之一是阿尔茨海默病,这是一种目前没有有效诊断生物标志物或治疗方法的痴呆症。它在女性中较高的患病率使得有必要研究可能参与和/或参与其发展的途径/系统,以及那些可能受激素因素影响的途径/系统,在这种情况下,是雌二醇水平。从这个意义上说,在科学界正在研究的系统之一是脑肾素-血管紧张素系统及其调节蛋白水解酶。该系统受雌激素的强烈调节,并通过血管紧张素IV受体(也被认为是胰岛素调节氨基肽酶(IRAP))与脑葡萄糖代谢有关。由于阿尔茨海默病患者的脑糖代谢高度受损,因此有必要了解这一过程中各系统的组成要素及其功能,即脑肾素-血管紧张素系统、雌二醇和与胰岛素依赖性葡萄糖转运蛋白4 (GLUT4)共定位于脑组织的酶和受体IRAP。了解它们之间的联系可以揭示这种疾病的分子机制,并提供新的诊断和治疗靶点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Alzheimer's disease: Is there a relationship between brain renin-angiotensin system, estradiol and glucose transporter-4 (GLUT-4)?
One of the diseases more related to the continuous aging of the population is Alzheimer's disease, which is a type of dementia currently without either effective diagnosis biomarkers or treatments. Its higher prevalence in women makes it necessary to study pathways/systems that could participate and/or be involved in its development, as well as those that could be affected by hormonal factors, which, in this case, are estradiol levels. In this sense, one of the systems under study that is gaining special relevance in the scientific community is the brain renin-angiotensin system and its regulatory proteolytic enzymes. This system is strongly modulated by estrogens, and it is also connected with the cerebral glucose metabolism through the angiotensin IV receptor, also recognized as the insulin-regulated aminopeptidase (IRAP). Due to the fact that the cerebral glucose metabolism is highly compromised in patients with Alzheimer's disease, it is necessary to know the elements of the systems and their functions in this process, namely, the cerebral renin-angiotensin system, estradiol and IRAP, an enzyme and receptor co-localized in brain tissue with the insulin-dependent glucose transporter 4 (GLUT4). Knowledge of the connection between them could shed light on the molecular mechanisms of this disease and also provide new diagnostic and therapeutic targets.
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来源期刊
AIMS Molecular Science
AIMS Molecular Science BIOCHEMISTRY & MOLECULAR BIOLOGY-
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