基质金属蛋白酶(MMPs) -1, -8, -13与牙周病的关系综述

IF 0.7 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Fazle Khuda, Nur Najmi Mohamad Anuar, B. Baharin, Nurrul Shaqinah Nasruddin
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引用次数: 6

摘要

基质金属蛋白酶(MMPs)是牙周病中最重要的内肽酶之一,通常降解牙周支撑组织的细胞外基质(ECM)成分,导致牙齿脱落。在MMP家族中,也被称为胶原酶组的MMP-1、-8和-13在ECM胶原蛋白和非胶原蛋白物质的降解中起着至关重要的作用。在牙周炎患者的组织、龈沟液(GCF)和唾液中,MMP -1、-8和-13水平显著升高,这有助于解释疾病的进展模式。本文综述了MMP -1、-8和-13的结构、功能及其在牙周炎中的重要作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A mini review on the associations of matrix metalloproteinases (MMPs) -1, -8, -13 with periodontal disease
Matrix metalloproteinases (MMPs) are one of the most important endopeptidases in periodontal disease that generally degrade extracellular matrix (ECM) components of periodontal supporting tissues, leading to tooth loss. Among the MMP family, MMP-1, -8 and -13, which are also known as the collagenase group, play a vital role in the degradation of ECM collagen and non-collagen substances. Elevated levels of MMP -1, -8 and -13 are markedly significant within tissue, gingival crevicular fluid (GCF), and saliva of patients with periodontitis, which help to explain the progression pattern of the disease. This review provides an overview of MMP -1, -8, and -13 on their structures, functions and their critical role in periodontitis.
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来源期刊
AIMS Molecular Science
AIMS Molecular Science BIOCHEMISTRY & MOLECULAR BIOLOGY-
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