多发性硬化症和过敏性疾病:有关系吗?

IF 0.9 Q4 IMMUNOLOGY
L. Aielli, Federica Serra, E. Costantini
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引用次数: 0

摘要

免疫系统紊乱是多种疾病的特征,如多发性硬化症(MS)和过敏性疾病(AD)。在MS中,t -辅助性(Th)1细胞表型与疾病的发病和长期演变有关。另一方面,过度的Th2细胞活性已在AD中得到证实。近年来,在同一地理区域观察到MS和AD同时增加,这对MS和AD免疫发病机制之间由Th1/Th2范式支持的互斥相关性提出了质疑,并对理解可能的重叠产生了兴趣。本文旨在讨论过去二十年来收集的关于MS和AD之间关系的文献,并对实验和流行病学研究进行了综述。尽管实验研究支持在两种疾病的免疫发病机制中涉及相同的细胞和分子,但结果并未提供AD和MS之间的可靠相关性。进一步的研究,增加对这两种疾病所涉及的细胞和分子机制的了解,可能有助于澄清它们之间是否存在积极或消极的联系,并为开发新疗法提供可能性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Multiple sclerosis and allergic diseases: is there a relationship?
Immune system disorders characterize various diseases such as multiple sclerosis (MS) and allergic diseases (AD). In MS, T-helper (Th)1 cell phenotype is responsible for the disease onset and long-term evolution. On the other hand, excessive Th2 cell activity has been demonstrated in AD. The simultaneous increase of MS and AD in the same geographical areas, observed in recent years, has questioned the mutually exclusive correlation between MS and AD immunopathogenesis supported by the Th1/Th2 paradigm and has moved the interest in understanding possible overlaps. This manuscript aims to discuss the literature, collected over the past two decades, about the association between MS and AD, and both experimental and epidemiological studies have been reviewed. The results do not provide a solid correlation between AD and MS, although experimental studies support the involvement of the same cells and molecules in the immunopathogenesis of both diseases. Further studies, increasing knowledge on the cellular and molecular mechanisms involved in these two disorders, could help to clarify if a positive or negative association links them and provide the possibility for the development of new therapies.
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