血培养和管凝集血清学试验对疟疾阴性患者伤寒诊断的评估:一项为期一年的医院研究

IF 0.2 Q4 HEALTH CARE SCIENCES & SERVICES
K. Nirmal, Vikas Saini, Nadeem Ahmad, Narendra Pal Singh
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引用次数: 0

摘要

沙门氏菌血清型,包括伤寒沙门氏菌、A型副伤寒沙门氏菌、B型副伤寒沙门氏菌和C型副伤寒沙门氏菌,可导致被称为伤寒的全身性、持续性发热性疾病。各种基于抗体的检测被用于诊断伤寒。本研究是在印度东德里的一家三级保健医院进行的,目的是评估用于诊断疟疾阴性患者伤寒的widal试验和血培养的性能。该研究于2021年7月至2022年6月在德里一家三级护理医院的微生物科进行。对包括成人和儿童在内的患者进行伤寒评估,并参与了一项对疟疾阴性发热患者的观察性前瞻性研究。静脉血在严格的无菌条件下采集,并进一步处理,进行伤寒血清和血培养试验。血培养阳性沙门氏菌的检出率为0.3%(30/ 10000 = 0.3%)。在药敏型中,伤寒沙门氏菌对环丙沙星(43.33%)、阿奇霉素(36.66%)和第三代头孢菌素的耐药率最高。在30例伤寒患者伤寒沙门氏菌血培养阳性的样本中,5例(17%)的维达尔试验呈阴性。30份样本全部血培养阳性,但只有25份样本的维达尔效价高于基线,即>1:64。虽然血培养是诊断伤寒的金标准,但维达尔试验确实在伤寒的诊断和管理中发挥作用,特别是在血培养阴性的疑似病例中,特别是在政府三级保健医院。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Assessment of blood culture and tube agglutination serology test for the diagnosis of typhoid fever amongst malaria-negative patients: a one-year hospital-based study
Salmonella serotypes, including Salmonella Typhi, S. Paratyphi A, S. Paratyphi B, and S. Paratyphi C, are responsible for the systemic, protracted febrile sickness known as typhoid fever. Various antibody-based tests are being used for diagnosing typhoid fever. This study was carried out to assess the performance of the widal test and blood culture for the diagnosis of typhoid fever among malaria-negative patients in a tertiary care hospital in east Delhi, India. The study was conducted from July 2021 to June 2022 in the Department of Microbiology of a tertiary care hospital in Delhi. Patients, including the adult and pediatric population, were evaluated for typhoid fever and participated in an observational, prospective study on febrile patients that was malaria-negative. Venous blood samples were obtained under strict aseptic conditions and further processed for widal serology and blood culture tests for typhoid fever. In our study, the prevalence of blood culture-positive Salmonella species was 0.3% (30/10,000 = 0.3%) Among antimicrobial susceptibility patterns, S. Typhi revealed the highest resistance rates for Ciprofloxacin (43.33%), Azithromycin (36.66%), and third-generation cephalosporins. Out of 30 blood culture-positive Salmonella Typhi of typhoid fever patients, 5 (17%) samples were negative for the Widal test. Among 30 samples, all were blood culture positive, but only 25 samples show Widal titer above the baseline i.e. >1:64. Although blood culture is the gold standard for the diagnosis of typhoid fever, the Widal test does play a role in the diagnosis and management of typhoid fever, especially in suspected cases when blood culture is negative, especially in government tertiary care hospitals.
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