了解动态:探讨肠道健康和饮食干预对类风湿关节炎炎症生物标志物的影响

A. Srivastava
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引用次数: 0

摘要

类风湿性关节炎(RA)是一种使人衰弱和致残的自身免疫性疾病,其特征是关节疼痛、僵硬和肌肉功能丧失。大约1%的人口患有这种疾病,30%的RA患者在发病后的10年内难以完成日常工作。此外,据观察,在40-70岁之间,妇女比男子受影响更大;任何年龄段的儿童也会受到影响。由于IL-6、细胞因子、TNF-α等促炎触发因素,它会导致疼痛的炎症和随后的软骨和骨骼破坏,而在开始时没有明显的迹象。目前治疗类风湿性关节炎的药物治疗价格昂贵,长期使用对整体健康有害。肠道异常可能是类风湿性关节炎疾病活动的潜在原因。类风湿关节炎在先天条件下始于肠道,并可能在家族中遗传。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Understanding Dynamics: Probing into Gut Health and DietaryInterventions on Biomarkers of Inflammation in Rheumatoid Arthritis
It Rheumatoid arthritis (RA) is a debilitating and disabling autoimmune disorder characterized by joint pain, stiffness and lost muscle function. About 1% of population accounts for individuals suffering from this disease and 30% of RA patients find it difficult to perform daily task in a span of next 10 years of the onset of the condition. Moreover, it is observed that women are more affected than men between the ages of 40-70 years; children are also affected at any age. It causes painful inflammation and subsequent cartilage and bone destruction owing to pro inflammatory triggers like IL-6, cytokines, TNF-α with no clear signs in the starting. Current drug treatment for treating rheumatoid arthritis is expensive and deleterious on overall health on long-term use. Gut abnormalities can be an underlying cause of disease activity in RA. RA in a pre-disposed condition starts in the gut and may run in the families.
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