Changes of serum uric acid in patients with cerebral infarction in different neurological deficits and their relationship with short-term prognosis

Objective To investigate the changes of serum uric acid (SUA)and its relationship with short-term prognosis in patients with cerebral infarction due to different neurological deficits. Methods A retrospective study was performed on 112 cases of patients with cerebral infarction due to different neurological deficits who were admitted from February 2014 to December 2016.According to the National Institutes of Health Stroke Scale (NIHSS), patients were divided into the mild-moderate group (n=51)and the moderate-severe group (n=61). The NIHSS score was statistically analyzed after the 1st and 7th day onset of disease, respectively, the SUA level was determined, and the prognosis of the patients was assessed by the improved RANKIN scale (mRS)at the 1st and 3rd month. Results In the moderate-severe group, level of SUAday7 was significantly lower than that of SUAday1, the difference value of SUA in the moderate-severe group was significantly higher than that in the mild-moderate group, and the difference had statistical significance (P<0.05); the prognosis in the mild-moderate group was good at the 1st and 3rd month after onset, while in the moderate-severe group, 31 patients had poor prognosis at the end of the first month, 20 patients had poor prognosis at the end of the third month.The logistic regression analysis showed that ΔSUA and NIHSSday1 were the risk factors of prognosis at the end of the first posterior cerebral infarction (P<0.05), NIHSSday1 was a risk factor for prognosis at the end of 3rd month after cerebral infarction (P<0.05). Conclusion The NIHSS score is the risk factor of prognosis in the first day of cerebral infarction, while the reduction of SUA is related to the short-term prognosis. Key words: Neurological deficit; Cerebral infarction; Uric acid; Short-term prognosis