A comprehensive examination of human myeloid cells reveals flaws in in vitro models of in vivo biology

Macrophages square measure innate immune cells that square measure resident in each tissue, have physiological state roles, and reply to infection or injury. The distinct practical roles of macrophages square measure mirrored in their transcriptional phenotypes: tissue atlases of mouse macrophages, as an example, have given nice insight into their quality and heterogeneity much of our understanding of phagocyte biology, together with several of the molecular mechanisms of innate immune communication; have arisen from mouse cistron knockout studies. However, crossspecies comparisons of immune cells highlight variations between mouse and human.