维持性血液透析患者血脂变化及其与胰岛素抵抗的关系

临床荟萃 Pub Date : 2010-03-20 DOI:10.3760/CMA.J.ISSN.1673-4238.2010.003.006

Li-li Wang, Xiaoliang Pang, Li-Hua Wang, Dong Wang

{"title":"维持性血液透析患者血脂变化及其与胰岛素抵抗的关系","authors":"Li-li Wang, Xiaoliang Pang, Li-Hua Wang, Dong Wang","doi":"10.3760/CMA.J.ISSN.1673-4238.2010.003.006","DOIUrl":null,"url":null,"abstract":"Objective To observe the fasting glucose,serum insulin and lipid level in maintenance hemodialysis,calculate the insulin resistance index(HOMA-IR) and the insulin sensitivity index(ISI) to evaluate the relationship with insulin resistance(IR),to carry out correlation analysis with the corresponding index of 30 health examinations.Methods Forty-eight maintenance hemodialysis patients(observation group) and 30 healthy volunteers(control group) were included in this study.Fasting plasma glucose(FPG),glycosylated hemoglobin(HbA1c),fasting insulin(FIns),blood urea nitrogen(BUN),creatinine(Cr),uric acid(UA) and lipid indexes were measured,and the relationship of them analyzed.Results BUN,Cr,UA,FIns,HbA1c,FPG and HOMA-IR were significantly higher in patients than in controls,but total cholesterol(TC),high density lipid protein cholesterol(HDL-C) and low density lipid protein cholesterol(LDL-C) were significantly lower in controls,BUN(24.9±5.8) mmol/L vs(5.0±1.6) mmol/L(P0.05);Cr(820±222) μmol/L vs(73± 17) μmol/L(P0.05);UA(397±96) μmol/L vs(298±79) μmol/L(P0.05);FIns(16±11) mU/L vs(11± 5) mU/L(P0.05);FPG(6.1±1.6) mmol/L vs(5.1±0.6) mmol/L(P0.05);HOMA-IR 4.3±3.2 vs 2.4±1.2(P0.05);TC(4.2±1.2) mmol/L vs(5.3±1.1) mmol/L(P0.05);HDL-C(1.3±0.5) mmol/L vs(1.6±0.4) mmol/L(P0.01);LDL-C(3.0±1.0) mmol/L vs(4.1±1.1) mmol/L(P0.05).TC was negative correlated with FPG(r=-0.3482,P0.05).HDL-C was negative correlated with FIns(r=-0.2603,P0.05).LDL-C was negative correlated with FPG(r=-0.3289,P0.05),triglyceride was positively correlated with FPG and HOMA-IR(r=0.371,0.368,P0.05).Conclusion Lipid metabolic disorder existed in maintenance hemodialysis patients,HOMA-IR may participate in them.","PeriodicalId":10383,"journal":{"name":"临床荟萃","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2010-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The variation of lipid in maintenance hemodialysis and the relationship with insulin resistance\",\"authors\":\"Li-li Wang, Xiaoliang Pang, Li-Hua Wang, Dong Wang\",\"doi\":\"10.3760/CMA.J.ISSN.1673-4238.2010.003.006\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objective To observe the fasting glucose,serum insulin and lipid level in maintenance hemodialysis,calculate the insulin resistance index(HOMA-IR) and the insulin sensitivity index(ISI) to evaluate the relationship with insulin resistance(IR),to carry out correlation analysis with the corresponding index of 30 health examinations.Methods Forty-eight maintenance hemodialysis patients(observation group) and 30 healthy volunteers(control group) were included in this study.Fasting plasma glucose(FPG),glycosylated hemoglobin(HbA1c),fasting insulin(FIns),blood urea nitrogen(BUN),creatinine(Cr),uric acid(UA) and lipid indexes were measured,and the relationship of them analyzed.Results BUN,Cr,UA,FIns,HbA1c,FPG and HOMA-IR were significantly higher in patients than in controls,but total cholesterol(TC),high density lipid protein cholesterol(HDL-C) and low density lipid protein cholesterol(LDL-C) were significantly lower in controls,BUN(24.9±5.8) mmol/L vs(5.0±1.6) mmol/L(P0.05);Cr(820±222) μmol/L vs(73± 17) μmol/L(P0.05);UA(397±96) μmol/L vs(298±79) μmol/L(P0.05);FIns(16±11) mU/L vs(11± 5) mU/L(P0.05);FPG(6.1±1.6) mmol/L vs(5.1±0.6) mmol/L(P0.05);HOMA-IR 4.3±3.2 vs 2.4±1.2(P0.05);TC(4.2±1.2) mmol/L vs(5.3±1.1) mmol/L(P0.05);HDL-C(1.3±0.5) mmol/L vs(1.6±0.4) mmol/L(P0.01);LDL-C(3.0±1.0) mmol/L vs(4.1±1.1) mmol/L(P0.05).TC was negative correlated with FPG(r=-0.3482,P0.05).HDL-C was negative correlated with FIns(r=-0.2603,P0.05).LDL-C was negative correlated with FPG(r=-0.3289,P0.05),triglyceride was positively correlated with FPG and HOMA-IR(r=0.371,0.368,P0.05).Conclusion Lipid metabolic disorder existed in maintenance hemodialysis patients,HOMA-IR may participate in them.\",\"PeriodicalId\":10383,\"journal\":{\"name\":\"临床荟萃\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2010-03-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"临床荟萃\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3760/CMA.J.ISSN.1673-4238.2010.003.006\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"临床荟萃","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.1673-4238.2010.003.006","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

摘要

目的观察维持性血液透析患者的空腹血糖、血清胰岛素和血脂水平，计算胰岛素抵抗指数(HOMA-IR)和胰岛素敏感性指数(ISI)，评价其与胰岛素抵抗(IR)的关系，并与30项健康检查的相应指标进行相关性分析。方法选取维持性血液透析患者48例(观察组)和健康志愿者30例(对照组)作为研究对象。测定空腹血糖(FPG)、糖化血红蛋白(HbA1c)、空腹胰岛素(FIns)、尿素氮(BUN)、肌酐(Cr)、尿酸(UA)、血脂等指标，并分析它们之间的关系。结果患者BUN、Cr、UA、FIns、HbA1c、FPG、HOMA-IR均显著高于对照组，但对照组总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)显著低于对照组，BUN(24.9±5.8)mmol/L vs(5.0±1.6)mmol/L(P0.05)，Cr(820±222)μmol/L vs(73±17)μmol/L(P0.05)，UA(397±96)μmol/L vs(298±79)μmol/L(P0.05)，FIns(16±11)μmol/L vs(11±5)μmol/L(P0.05)，FPG(6.1±1.6)mmol/L vs(5.1±0.6)mmol/L(P0.05)， HOMA-IR 4.3±3.2 vs2.4±1.2 (P0.05); TC(4.2±1.2)更易/ L和(5.3±1.1)更易/ L (P0.05),高密度脂蛋白胆固醇(1.3±0.5)更易/ L和(1.6±0.4)更易/ L (P0.01);低密度(3.0±1.0)更易/ L和(4.1±1.1)更易/ L (P0.05)。TC与FPG呈负相关(r=-0.3482,P0.05)。HDL-C与FIns呈负相关(r=-0.2603,P0.05)。LDL-C与FPG呈负相关(r=-0.3289,P0.05)，甘油三酯与FPG、HOMA-IR呈正相关(r=0.371,0.368,P0.05)。结论维持性血液透析患者存在脂质代谢紊乱，HOMA-IR可能参与其中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

The variation of lipid in maintenance hemodialysis and the relationship with insulin resistance

Objective To observe the fasting glucose,serum insulin and lipid level in maintenance hemodialysis,calculate the insulin resistance index(HOMA-IR) and the insulin sensitivity index(ISI) to evaluate the relationship with insulin resistance(IR),to carry out correlation analysis with the corresponding index of 30 health examinations.Methods Forty-eight maintenance hemodialysis patients(observation group) and 30 healthy volunteers(control group) were included in this study.Fasting plasma glucose(FPG),glycosylated hemoglobin(HbA1c),fasting insulin(FIns),blood urea nitrogen(BUN),creatinine(Cr),uric acid(UA) and lipid indexes were measured,and the relationship of them analyzed.Results BUN,Cr,UA,FIns,HbA1c,FPG and HOMA-IR were significantly higher in patients than in controls,but total cholesterol(TC),high density lipid protein cholesterol(HDL-C) and low density lipid protein cholesterol(LDL-C) were significantly lower in controls,BUN(24.9±5.8) mmol/L vs(5.0±1.6) mmol/L(P0.05);Cr(820±222) μmol/L vs(73± 17) μmol/L(P0.05);UA(397±96) μmol/L vs(298±79) μmol/L(P0.05);FIns(16±11) mU/L vs(11± 5) mU/L(P0.05);FPG(6.1±1.6) mmol/L vs(5.1±0.6) mmol/L(P0.05);HOMA-IR 4.3±3.2 vs 2.4±1.2(P0.05);TC(4.2±1.2) mmol/L vs(5.3±1.1) mmol/L(P0.05);HDL-C(1.3±0.5) mmol/L vs(1.6±0.4) mmol/L(P0.01);LDL-C(3.0±1.0) mmol/L vs(4.1±1.1) mmol/L(P0.05).TC was negative correlated with FPG(r=-0.3482,P0.05).HDL-C was negative correlated with FIns(r=-0.2603,P0.05).LDL-C was negative correlated with FPG(r=-0.3289,P0.05),triglyceride was positively correlated with FPG and HOMA-IR(r=0.371,0.368,P0.05).Conclusion Lipid metabolic disorder existed in maintenance hemodialysis patients,HOMA-IR may participate in them.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

临床荟萃

自引率

0.00%

发文量

26966

期刊介绍： Clinical Focus (monthly) magazine was founded in 1986. It is an academic journal approved by the State Administration of Press and Publication, under the supervision of the Hebei Provincial Department of Education, and sponsored by Hebei Medical University. It has a clinical guidance role in the internal medicine community. This journal mainly reports on the latest and most important research, breakthroughs, discoveries related to internal medicine, as well as the current development status of internal medicine. This journal is mainly for domestic clinicians and researchers. Its main columns include special topics, reviews, treatises, short treatises, meta-analysis, guideline interpretation, case reports, clinical case discussions, rural physician columns, lectures, reviews, etc. Awards Chinese Periodical Array "Double Effect Journal" Chinese Core Journal of Internal Medicine (1992-2004, 1st-4th session) RCCSE China Core Academic Journal (A-)