与环孢素相比,他克莫司治疗的肾移植受者外周血淋巴细胞对内源性糖皮质激素的敏感性更高。

Gulimire Muhetaer, H. Takeuchi, Sogo Akizuki, H. Iwamoto, M. Shimazu, S. Unezaki, T. Hirano
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引用次数: 2

摘要

淋巴细胞对内源性糖皮质激素皮质醇的敏感性可能是肾移植受者安全减少和停用类固醇的生物学标志物。我们比较了接受他克莫司(Tac)和环孢素治疗的移植受者外周血淋巴细胞对皮质醇的敏感性。在44例肾移植患者中,研究了皮质醇对t细胞有丝分裂原刺激的外周血淋巴细胞增殖的抑制作用,这些患者要么减少了类固醇治疗,要么停止了类固醇治疗。44例患者中有20例采用Tac治疗,其余24例采用环孢素A (CyA)治疗。比较两组患者淋巴细胞对皮质醇的敏感性。Tac组和CyA组皮质醇IC50值分别为0.09±0.12和14.2±12.7 ng/ml。tac治疗组淋巴细胞对皮质醇的敏感性显著高于cya治疗组(p = 0.0283)。另一方面,类固醇戒断综合征的发生率和血清肌酐浓度升高在Tac组和CyA组之间无显著差异。taca组患者淋巴细胞对皮质醇的敏感性高于cya组。由于外周淋巴细胞的皮质醇敏感性被认为是类固醇安全停药的预测指标,Tac给药有望帮助长期肾移植受者成功停药。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Higher Sensitivity of Peripheral Blood Lymphocytes to Endogenous Glucocorticoid in Renal Transplant Recipients Treated With Tacrolimus, as Compared to Those Treated With Cyclosporine.
Lymphocyte sensitivity to endogenous glucocorticoid cortisol could be a biological marker for safe reduction and withdrawal of steroids in renal transplant recipients. We compared peripheral lymphocyte sensitivity with cortisol between transplant recipients treated with tacrolimus (Tac) and those treated with cyclosporine. The suppressive efficacies of cortisol against T-cell mitogen-stimulated proliferation of peripheral lymphocytes were investigated in 44 renal transplant patients, who either had reduced or been withdrawn from steroid treatment. Twenty of the 44 patients were treated with Tac, and the other 24 patients were treated with cyclosporine A (CyA). The lymphocyte sensitivity to cortisol was compared between these two patient groups. The cortisol IC50 values in the Tac and CyA groups were 0.09 ± 0.12 and 14.2 ± 12.7 ng/ml, respectively. Lymphocyte sensitivity to cortisol in the Tac-treated group was significantly higher than that in the CyA-treated group (p = 0.0283). On the other hand, incidences of steroid withdrawal syndrome and increases in serum creatinine concentration were not significantly different between the Tac and CyA groups. Lymphocyte sensitivity to cortisol was higher in the Tac-treated patients than that in the CyA-treated ones. Since the cortisol sensitivity of peripheral lymphocytes is suggested to be a predictive marker for safe steroid withdrawal, Tac administration shows promise in aiding successful withdrawal of steroid treatment in long-term renal transplant recipients.
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来源期刊
Cell medicine
Cell medicine MEDICINE, RESEARCH & EXPERIMENTAL-
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