Nataly V. Hasiuk, Nataliya A. Yaskiv, Pavlo V. Leonenko, V. Radchuk
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引用次数: 0
摘要
目的:分析总结近10年来关于慢性复发性口腔炎的现代预防方法、病因、病机及治疗的现代科学文献资料。材料与方法:基于Scopus、Web of Science、MedLine、PubMed、NCBI等数据库,对研究时间不超过10年的CRAS的病因、发病机制、防治等现代科学文献数据进行分析归纳,包括文献综述和临床试验结果。结论:慢性复发性口腔炎的预防需要综合、个体化治疗。由于这种疾病的多变性,将其减少到一个原因变得严重,这使得预测复发的原因和预防问题的解决变得更加困难。不同患者诱发CRAS形成的触发机制不同(压力、机械障碍、营养性质、缺乏维生素或微量元素、感染等)。然而,免疫发病机制可能是引起口疮复发的主要诱因之一。由于对发病因素的认识不完善,预防慢性复发性口疮口炎的目的是增加新病灶出现的间隔时间,减少口疮的数量和大小,所以换句话说,它是继发性的。
Modern Approach to Prevention of Chronic Recurrent Aphthous Stomatitis
Aim: To analyse and summarize the data of modern scientific literature for the last 10 years on modern approaches to the prevention of chronic recurrent aphthous stomatitis, etiology, pathogenesis and treatment of this disease. Materials and Methods: Analysis and generalization of data from the modern scientific literature on the etiology, pathogenesis, prevention and treatment of CRAS based on databases such as Scopus, Web of Science, MedLine, PubMed, NCBI, the study of which does not exceed 10 years, including literature reviews and results of clinical trials. Conclusions: The prevention of chronic recurrent aphthous stomatitis requires a comprehensive and individualized approach to solve this issue. Reduction of this disease to one cause becomes serious due to its polyetiology, which makes it more difficult to predict the causes of recurrence and solution of the prevention issue. Trigger mechanisms that provoke the formation of CRAS differ in various patients (stress, mechanical disorders, the nature of nutrition, lack of vitamins or trace elements, infections, etc.). However, the immunopathogenetic mechanism may be a common link for the main triggers of the aphthae recurrence emergence. Due to the imperfect understanding of etiopathogenetic factors, the prevention of chronic recurrent aphthous stomatitis is aimed at increasing the intervals between the appearance of new lesions, reducing the number of aphthae and their size, so in other words, it is secondary.