A Case Report of Undifferentiated Pancreatic Carcinoma

We report a rare case of an Undifferentiated Carcinoma of Pancreas (UCP) in a 21-year-young man, who presented with painless jaundice, dyspnea and dry cough. Weight loss for one month. No history of fever. It constitutes less than 1% of pancreatic exocrine neoplasia. Its histopathologic properties remain poorly understood. LFT shows mild increase in transaminases and alakalinephosatase. However, CA19.9 and serum electrolytes were normal. Imaging studies revealed a lobulated solid hypo enhancing mass noted in the pancreatic duodenal groove encasing the common hepatic artery, gastroduodenal artery and partly encasing main portal vein with likely involvement of part of the head and uncinate process of pancreas measuring 6.6 × 4.3 × 3.5 cm in the head of the pancreas. A EUS guided Fine Needle Biopsy (FNB) was performed and microscopy showed a cellular neoplasm composed of pleomorphic mononuclear cells (IMP3-positive; LCA, and CD68 negative) and occasional multinucleated giant cells (LCA, and CD68-positive; pancytokeratin, and EMA-negative) consistent with UCP. Evidence supports that the giant cells are non-neoplastic and of histiocytic origin.