抗tnf -α治疗创伤后应激障碍共病性疼痛的潜在治疗方法

Q4 Medicine

Douleur Et Analgesie Pub Date : 2022-01-01 DOI:10.3166/dea-2022-0193

H.M.C. Illouz

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引用次数: 0

摘要

创伤后应激障碍(PTSD)是一种暴露于创伤性事件后发生的精神障碍。慢性疼痛是创伤后应激障碍患者最常见的合并症之一，在这些患者中检测到较高水平的促炎细胞因子肿瘤坏死因子α (TNF-α)。在最近的一项研究中，Dib等(2021)使用创伤后应激障碍的单次延长应激(SPS)动物模型，用沙利度胺或抗TNF-α抗体阻断TNF-α。通过这种方法，作者阻止了sps大鼠的机械异常性疼痛和热痛觉过敏。

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Anti-TNF-α Therapy as a Potential Treatment for Comorbid Pain in Post-traumatic Stress Disorder

Post-traumatic stress disorder (PTSD) is a psychiatric disorder that occurs after exposure to a traumatic event. Chronic pain is one of the most frequent comorbidities for patients with PTSD and higher levels of the proinflammatory cytokine tumor necrosis factor α (TNF-α) have been detected in these patients. In a recent study, Dib et al (2021) used the single prolonged stress (SPS) animal model of PTSD and blocked TNF-α with either thalidomide or anti-TNF-α antibody. This way, the authors prevented mechanical allodynia and thermal hyperalgesia in SPS-rats.

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来源期刊

Douleur Et Analgesie 医学-临床神经学

CiteScore

0.30

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Douleur et Analgésie, première revue internationale francophone consacrée à la douleur, a été créée en 1988. De par la qualité scientifique et l’indépendance de ses publications, ce trimestriel a reçu d’emblée un accueil favorable auprès des chercheurs et cliniciens spécialisés dans le domaine. Á l’occasion de la reprise de la revue en 2006 par les Éditions Springer, le comité éditorial a souhaité s’ouvrir davantage à la francophonie, y compris nord américaine, pour mieux partager les connaissances et renforcer la valeur scientifique de la revue.