THE ROLE OF INTESTINAL MICROBIOTA IN THE PATHOGENESIS OF SEPSIS PROGRESSION

Background. Sepsis is a global public health problem and is associated with high mortality rates in all countries. According to recent views, sepsis is defned as life-threatening organ dysfunction caused by an unregulated response of the host to infection. Objective. To analyze the results of scientifc studies confrming the key role of intestinal dysbiosis in the pathophysiology of sepsis. Material and methods. A qualitative analysis of 34 Russian-language and English-language sources concerning the role of the intestinal microbiota in the onset of sepsis was carried out. Results. It has been established that intestinal microbiota plays an important role in the etiology, pathogenesis and treatment of sepsis and its disbalance can trigger the development of sepsis of various etiologies, mainly gram-negative. Conclusions. The analysis of the literature indicates that bacterial translocation can be natural provided that the immune system functions properly. Intestinal microbiota plays one of the leading roles in the development of sepsis. The use of probiotics and transplantation of intestinal microbiota contribute greatly to the treatment and prevention of sepsis in ICU patients.