Analgesic effects of oxycodone hydrochloride injection after laparoscopic cholecystectomy and influence on substance P, 5-hydroxytryptamine, and patient-controlled intravenous analgesia

Abstract Introduction We sought out to evaluate the effects of oxycodone hydrochloride injection on laparoscopic cholecystectomy (LC), substance P, 5-hydroxytryptamine (5-HT), and patient-controlled intravenous analgesia (PCIA). Materials and Methods A total of 120 eligible patients were randomly divided into an observation group (n=60) and control group (n=60). Oxycodone (0.07 mg/kg) and fentanyl (0.7 μg/kg) were intravenously injected during LC. Substance P and 5-HT were detected by ELISA. Results Heart rate (HR), mean arterial pressure (MAP), and blood oxygen saturation (SpO2) were recorded. Visual analogue scale (VAS), Ramsay scores, and incidence rates of adverse reactions were recorded. The observation group was less prone to agitation, with less affected HR, MAP and SpO2 during recovery. Before and after extubation, and upon leaving the recovery room, substance P and 5-HT increased more slowly in the observation group. After extubation, the control group had higher VAS and Ramsay scores and a higher incidence rate of adverse reactions. Using oxycodone before the end of LC does not delay awakening or affect extubation, but reduces hemodynamic fluctuations, incidence of agitation and release of substance P and 5-HT. It has high safety and stable circulation during recovery. Conclusions Oxycodone used in PCIA after LC effectively mitigates postoperative pain, with milder adverse reactions, which is superior to fentanyl.