代谢组学和家畜基因组学:表型前沿及其在动物育种中的应用

IF 3.2 2区 农林科学 Q1 AGRICULTURE, DAIRY & ANIMAL SCIENCE
L. Fontanesi
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引用次数: 53

摘要

代谢组学是代谢组学分析的新兴领域,它识别、量化和表征生物样本(如牛奶、血浆和血清)中的大量代谢物,为所谓的中间表型提供有趣的见解,这些中间表型位于基因组空间(或水平)和最终或外部表型之间,在牲畜中可能是生产性状,如生长速度、产奶量、脂肪沉积、以及其他与经济相关的特征。•代谢组学应用于动物育种可能成为“下一代表型”方法的基石,这些方法需要完善和改进性状描述,反过来,提高动物育种价值的预测,以应对传统和新的选择计划目标。•代谢组学与牲畜基因组学的整合仅在少数具有前景的研究中提出。•迄今在牛和猪中描述的与代谢型(mGWAS)的全基因组关联研究已将基因组变异性与相关生物体液中的代谢型水平联系起来。•基于系统遗传学概念的网络重建方法已被应用于解开代谢组学信息的复杂性,并将代谢组学与其他组学数据联系起来。•利用代谢型可以更好地定义新的和传统的性状以及相关的遗传结构,为动物育种中的新应用提供了机会。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Metabolomics and livestock genomics: Insights into a phenotyping frontier and its applications in animal breeding
Implications Metabolomics is the emerging field of metabolome analysis that identify, quantify, and characterize a large number of metabolites in biological samples (e.g., milk, plasma, and serum), providing interesting insights into the so called intermediate phenotypes that lie in the middle between the genomic space (or level) and the final or external phenotypes, that in livestock might be production traits such as growth rate, milk production, fat deposition, and other economic relevant traits. • Metabolomics applied to animal breeding might become a cornerstone of the “next generation phenotyping” approaches that are needed to refine and improve trait description and, in turn, to improve prediction of the breeding values of the animals to cope with traditional and new objectives of the selection programs. • Integration of metabolomics with livestock genomics has been presented in just few studies with promising perspectives. • Genome-wide association studies with metabotypes (mGWAS) described thus far in cattle and pigs have linked genomic variability with metabotype levels in relevant biofluids. • Network reconstruction methodologies based on systems genetics concepts have been applied to disentangle the complexity of metabolomics information and linking metabolomics with other omics data. • New and conventional traits and related genetic architecture could be better defined using metabotypes opening opportunities for novel applications in animal breeding.
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来源期刊
Animal Frontiers
Animal Frontiers Veterinary-Food Animals
CiteScore
6.50
自引率
5.60%
发文量
74
期刊介绍: Animal Frontiers is the official journal of the following globally active professional animal science societies: ASAS, the American Society of Animal Science CSAS, the Canadian Society of Animal Science EAAP, the European Federation of Animal Science AMSA, the American Meat Science Association These organizations are dedicated to the advancement and dissemination of science-based knowledge concerning animal agriculture. Animal Frontiers provides a novel forum for innovative and timely perspectives that have relevance to understanding the complex dynamics at work through animal agriculture. Animal Frontiers publishes discussion and position papers that present several international perspectives on the status of high-impact, global issues in animal agriculture. Every issue will explore a theme of broad and current interest within animal science and animal agriculture.
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