{"title":"代谢组学和家畜基因组学:表型前沿及其在动物育种中的应用","authors":"L. Fontanesi","doi":"10.2527/AF.2016-0011","DOIUrl":null,"url":null,"abstract":"Implications Metabolomics is the emerging field of metabolome analysis that identify, quantify, and characterize a large number of metabolites in biological samples (e.g., milk, plasma, and serum), providing interesting insights into the so called intermediate phenotypes that lie in the middle between the genomic space (or level) and the final or external phenotypes, that in livestock might be production traits such as growth rate, milk production, fat deposition, and other economic relevant traits. • Metabolomics applied to animal breeding might become a cornerstone of the “next generation phenotyping” approaches that are needed to refine and improve trait description and, in turn, to improve prediction of the breeding values of the animals to cope with traditional and new objectives of the selection programs. • Integration of metabolomics with livestock genomics has been presented in just few studies with promising perspectives. • Genome-wide association studies with metabotypes (mGWAS) described thus far in cattle and pigs have linked genomic variability with metabotype levels in relevant biofluids. • Network reconstruction methodologies based on systems genetics concepts have been applied to disentangle the complexity of metabolomics information and linking metabolomics with other omics data. • New and conventional traits and related genetic architecture could be better defined using metabotypes opening opportunities for novel applications in animal breeding.","PeriodicalId":48645,"journal":{"name":"Animal Frontiers","volume":null,"pages":null},"PeriodicalIF":3.2000,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2527/AF.2016-0011","citationCount":"53","resultStr":"{\"title\":\"Metabolomics and livestock genomics: Insights into a phenotyping frontier and its applications in animal breeding\",\"authors\":\"L. Fontanesi\",\"doi\":\"10.2527/AF.2016-0011\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Implications Metabolomics is the emerging field of metabolome analysis that identify, quantify, and characterize a large number of metabolites in biological samples (e.g., milk, plasma, and serum), providing interesting insights into the so called intermediate phenotypes that lie in the middle between the genomic space (or level) and the final or external phenotypes, that in livestock might be production traits such as growth rate, milk production, fat deposition, and other economic relevant traits. • Metabolomics applied to animal breeding might become a cornerstone of the “next generation phenotyping” approaches that are needed to refine and improve trait description and, in turn, to improve prediction of the breeding values of the animals to cope with traditional and new objectives of the selection programs. • Integration of metabolomics with livestock genomics has been presented in just few studies with promising perspectives. • Genome-wide association studies with metabotypes (mGWAS) described thus far in cattle and pigs have linked genomic variability with metabotype levels in relevant biofluids. • Network reconstruction methodologies based on systems genetics concepts have been applied to disentangle the complexity of metabolomics information and linking metabolomics with other omics data. • New and conventional traits and related genetic architecture could be better defined using metabotypes opening opportunities for novel applications in animal breeding.\",\"PeriodicalId\":48645,\"journal\":{\"name\":\"Animal Frontiers\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.2000,\"publicationDate\":\"2016-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.2527/AF.2016-0011\",\"citationCount\":\"53\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Animal Frontiers\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://doi.org/10.2527/AF.2016-0011\",\"RegionNum\":2,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"AGRICULTURE, DAIRY & ANIMAL SCIENCE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Animal Frontiers","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.2527/AF.2016-0011","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"AGRICULTURE, DAIRY & ANIMAL SCIENCE","Score":null,"Total":0}
Metabolomics and livestock genomics: Insights into a phenotyping frontier and its applications in animal breeding
Implications Metabolomics is the emerging field of metabolome analysis that identify, quantify, and characterize a large number of metabolites in biological samples (e.g., milk, plasma, and serum), providing interesting insights into the so called intermediate phenotypes that lie in the middle between the genomic space (or level) and the final or external phenotypes, that in livestock might be production traits such as growth rate, milk production, fat deposition, and other economic relevant traits. • Metabolomics applied to animal breeding might become a cornerstone of the “next generation phenotyping” approaches that are needed to refine and improve trait description and, in turn, to improve prediction of the breeding values of the animals to cope with traditional and new objectives of the selection programs. • Integration of metabolomics with livestock genomics has been presented in just few studies with promising perspectives. • Genome-wide association studies with metabotypes (mGWAS) described thus far in cattle and pigs have linked genomic variability with metabotype levels in relevant biofluids. • Network reconstruction methodologies based on systems genetics concepts have been applied to disentangle the complexity of metabolomics information and linking metabolomics with other omics data. • New and conventional traits and related genetic architecture could be better defined using metabotypes opening opportunities for novel applications in animal breeding.
期刊介绍:
Animal Frontiers is the official journal of the following globally active professional animal science societies:
ASAS, the American Society of Animal Science
CSAS, the Canadian Society of Animal Science
EAAP, the European Federation of Animal Science
AMSA, the American Meat Science Association
These organizations are dedicated to the advancement and dissemination of science-based knowledge concerning animal agriculture. Animal Frontiers provides a novel forum for innovative and timely perspectives that have relevance to understanding the complex dynamics at work through animal agriculture. Animal Frontiers publishes discussion and position papers that present several international perspectives on the status of high-impact, global issues in animal agriculture. Every issue will explore a theme of broad and current interest within animal science and animal agriculture.