糖尿病中母体、胎盘和胎儿的代谢

IF 0.2 4区医学 Q4 MEDICINE, GENERAL & INTERNAL

Srpski arhiv za celokupno lekarstvo Pub Date : 2023-01-01 DOI:10.2298/sarh221021012d

S. Dugalić, J. Todorović, Maja Macura, B. Gutic, Miloš Milinčić, Dragana D Božić, Milica Stojiljković, Milica Petronijevic, Luka de, I. Pantić, M. Perović, B. Parapid, M. Gojnić

{"title":"糖尿病中母体、胎盘和胎儿的代谢","authors":"S. Dugalić, J. Todorović, Maja Macura, B. Gutic, Miloš Milinčić, Dragana D Božić, Milica Stojiljković, Milica Petronijevic, Luka de, I. Pantić, M. Perović, B. Parapid, M. Gojnić","doi":"10.2298/sarh221021012d","DOIUrl":null,"url":null,"abstract":"Metabolic changes occur due to the effects of placental hormones such as human chorionic gonadotropin and human placental lactogen in normal pregnancies. These effects enable the development of insulin resistance among all pregnant women that is them ost significantly pronounced in the third trimester. In pregnancies complicated with pre-gestational or gestational diabetes mellitus these changes are more intensive as they affect fetoplacental unit. In pregnancies complicated with diabetes the increased number of placental macrophages leads to the increased production of different cytokines which include leptin, tumour necrosis factor alpha and interleukins. This review addresses placental vascular changes that lead to adverse pregnancy outcomes, along with the effects of the maternal hyperglycemia and fetal hyperinsulinemia.","PeriodicalId":22263,"journal":{"name":"Srpski arhiv za celokupno lekarstvo","volume":"1 1","pages":""},"PeriodicalIF":0.2000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Metabolism of the mother, placenta and fetus in diabetes\",\"authors\":\"S. Dugalić, J. Todorović, Maja Macura, B. Gutic, Miloš Milinčić, Dragana D Božić, Milica Stojiljković, Milica Petronijevic, Luka de, I. Pantić, M. Perović, B. Parapid, M. Gojnić\",\"doi\":\"10.2298/sarh221021012d\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Metabolic changes occur due to the effects of placental hormones such as human chorionic gonadotropin and human placental lactogen in normal pregnancies. These effects enable the development of insulin resistance among all pregnant women that is them ost significantly pronounced in the third trimester. In pregnancies complicated with pre-gestational or gestational diabetes mellitus these changes are more intensive as they affect fetoplacental unit. In pregnancies complicated with diabetes the increased number of placental macrophages leads to the increased production of different cytokines which include leptin, tumour necrosis factor alpha and interleukins. This review addresses placental vascular changes that lead to adverse pregnancy outcomes, along with the effects of the maternal hyperglycemia and fetal hyperinsulinemia.\",\"PeriodicalId\":22263,\"journal\":{\"name\":\"Srpski arhiv za celokupno lekarstvo\",\"volume\":\"1 1\",\"pages\":\"\"},\"PeriodicalIF\":0.2000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Srpski arhiv za celokupno lekarstvo\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.2298/sarh221021012d\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Srpski arhiv za celokupno lekarstvo","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2298/sarh221021012d","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}

引用次数: 0

摘要

在正常妊娠中，由于胎盘激素如人绒毛膜促性腺激素和人胎盘乳原的影响，代谢发生变化。这些影响使所有孕妇产生胰岛素抵抗，在妊娠晚期最为明显。在妊娠合并妊娠前或妊娠期糖尿病，这些变化更强烈，因为他们影响胎儿胎盘单位。在合并糖尿病的妊娠中，胎盘巨噬细胞数量的增加导致不同细胞因子的产生增加，包括瘦素、肿瘤坏死因子α和白细胞介素。本文综述了胎盘血管改变导致不良妊娠结局，以及母体高血糖和胎儿高胰岛素血症的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Metabolism of the mother, placenta and fetus in diabetes

Metabolic changes occur due to the effects of placental hormones such as human chorionic gonadotropin and human placental lactogen in normal pregnancies. These effects enable the development of insulin resistance among all pregnant women that is them ost significantly pronounced in the third trimester. In pregnancies complicated with pre-gestational or gestational diabetes mellitus these changes are more intensive as they affect fetoplacental unit. In pregnancies complicated with diabetes the increased number of placental macrophages leads to the increased production of different cytokines which include leptin, tumour necrosis factor alpha and interleukins. This review addresses placental vascular changes that lead to adverse pregnancy outcomes, along with the effects of the maternal hyperglycemia and fetal hyperinsulinemia.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Srpski arhiv za celokupno lekarstvo MEDICINE, GENERAL & INTERNAL-

CiteScore

0.40

自引率

50.00%

发文量

104

审稿时长

4-8 weeks

期刊介绍： Srpski Arhiv Za Celokupno Lekarstvo (Serbian Archives of Medicine) is the Journal of the Serbian Medical Society, founded in 1872, which publishes articles by the members of the Serbian Medical Society, subscribers, as well as members of other associations of medical and related fields. The Journal publishes: original articles, communications, case reports, review articles, current topics, articles of history of medicine, articles for practitioners, articles related to the language of medicine, articles on medical ethics (clinical ethics, publication ethics, regulatory standards in medicine), congress and scientific meeting reports, professional news, book reviews, texts for "In memory of...", i.e. In memoriam and Promemoria columns, as well as comments and letters to the Editorial Board. All manuscripts under consideration in the Serbian Archives of Medicine may not be offered or be under consideration for publication elsewhere. Articles must not have been published elsewhere (in part or in full).