{"title":"用一种新颖的三参数逻辑函数建模痴呆和无痴呆死亡的累积发病率","authors":"Y. Cheng","doi":"10.2202/1557-4679.1183","DOIUrl":null,"url":null,"abstract":"Parametric modeling of univariate cumulative incidence functions and logistic models have been studied extensively. However, to the best of our knowledge, there is no study using logistic models to characterize cumulative incidence functions. In this paper, we propose a novel parametric model which is an extension of a widely-used four-parameter logistic function for dose-response curves. The modified model can accommodate various shapes of cumulative incidence functions and be easily implemented using standard statistical software. The simulation studies demonstrate that the proposed model is as efficient as or more efficient than its nonparametric counterpart when it is correctly specified, and outperforms the existing Gompertz model when the underlying cumulative incidence function is sigmoidal. The practical utility of the modified three-parameter logistic model is illustrated using the data from the Cache County Study of dementia.","PeriodicalId":50333,"journal":{"name":"International Journal of Biostatistics","volume":"5 1","pages":""},"PeriodicalIF":1.2000,"publicationDate":"2009-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2202/1557-4679.1183","citationCount":"18","resultStr":"{\"title\":\"Modeling Cumulative Incidences of Dementia and Dementia-Free Death Using a Novel Three-Parameter Logistic Function\",\"authors\":\"Y. Cheng\",\"doi\":\"10.2202/1557-4679.1183\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Parametric modeling of univariate cumulative incidence functions and logistic models have been studied extensively. However, to the best of our knowledge, there is no study using logistic models to characterize cumulative incidence functions. In this paper, we propose a novel parametric model which is an extension of a widely-used four-parameter logistic function for dose-response curves. The modified model can accommodate various shapes of cumulative incidence functions and be easily implemented using standard statistical software. The simulation studies demonstrate that the proposed model is as efficient as or more efficient than its nonparametric counterpart when it is correctly specified, and outperforms the existing Gompertz model when the underlying cumulative incidence function is sigmoidal. The practical utility of the modified three-parameter logistic model is illustrated using the data from the Cache County Study of dementia.\",\"PeriodicalId\":50333,\"journal\":{\"name\":\"International Journal of Biostatistics\",\"volume\":\"5 1\",\"pages\":\"\"},\"PeriodicalIF\":1.2000,\"publicationDate\":\"2009-11-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.2202/1557-4679.1183\",\"citationCount\":\"18\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Biostatistics\",\"FirstCategoryId\":\"100\",\"ListUrlMain\":\"https://doi.org/10.2202/1557-4679.1183\",\"RegionNum\":4,\"RegionCategory\":\"数学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Biostatistics","FirstCategoryId":"100","ListUrlMain":"https://doi.org/10.2202/1557-4679.1183","RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Modeling Cumulative Incidences of Dementia and Dementia-Free Death Using a Novel Three-Parameter Logistic Function
Parametric modeling of univariate cumulative incidence functions and logistic models have been studied extensively. However, to the best of our knowledge, there is no study using logistic models to characterize cumulative incidence functions. In this paper, we propose a novel parametric model which is an extension of a widely-used four-parameter logistic function for dose-response curves. The modified model can accommodate various shapes of cumulative incidence functions and be easily implemented using standard statistical software. The simulation studies demonstrate that the proposed model is as efficient as or more efficient than its nonparametric counterpart when it is correctly specified, and outperforms the existing Gompertz model when the underlying cumulative incidence function is sigmoidal. The practical utility of the modified three-parameter logistic model is illustrated using the data from the Cache County Study of dementia.
期刊介绍:
The International Journal of Biostatistics (IJB) seeks to publish new biostatistical models and methods, new statistical theory, as well as original applications of statistical methods, for important practical problems arising from the biological, medical, public health, and agricultural sciences with an emphasis on semiparametric methods. Given many alternatives to publish exist within biostatistics, IJB offers a place to publish for research in biostatistics focusing on modern methods, often based on machine-learning and other data-adaptive methodologies, as well as providing a unique reading experience that compels the author to be explicit about the statistical inference problem addressed by the paper. IJB is intended that the journal cover the entire range of biostatistics, from theoretical advances to relevant and sensible translations of a practical problem into a statistical framework. Electronic publication also allows for data and software code to be appended, and opens the door for reproducible research allowing readers to easily replicate analyses described in a paper. Both original research and review articles will be warmly received, as will articles applying sound statistical methods to practical problems.