Ahué Koffi Marcellin, A. Kadja, Mamyrbekova-Bekro Janat Akhanovna, M. Tangui, V. David, Pirat Jean-Luc, Guiffrey Pascale, B. Yves-Alain
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引用次数: 0
摘要
本研究旨在分离鉴定塞内加尔红藓(Erythrina senegalensis DC)有效提取物粗甲醇提取物的活性成分。(蝶形花科)。采用液液萃取法获得氯仿提取物(粗甲醇提取物的选择性提取物)，并在小鼠模型中检测其对阿尔茨海默病的体内保护作用。在显示出有益的效果后，该提取物进行了色谱(开柱，高效液相色谱)和光谱(核磁共振)分析，以分离和表征可能是观察到的生物活性来源的植物化合物。首次从产自Côte d' ivivire的E. senegalensis中分离到黄酮类植物化合物osajin和cajaflavanone。
In vivo Neuroprotective Activity of the Chloroform Selective Extract from the Bark of Erythrina senegalensis DC. (Fabaceae) and Characterization of two Isolated Phytoconstituents
The present study aims to isolate and identify bioactive phytocompounds derived from the crude methanolic extract, an effective extract of Erythrina senegalensis DC. (Fabaceae). The chloroform extract (selective extract of the crude methanol extract) was obtained by liquidliquid extraction, then tested for its protective activity in vivo against Alzheimer's disease in a mouse model. After showing a beneficial effect, this extract underwent chromatographic (open column, HPLC) and spectroscopic (NMR) analyzes in order to isolate and characterize the phytocompounds which would be at the origin of the observed biological activities. Thus, two phycompounds of the flavonoid class: osajin and cajaflavanone, were isolated for the first time from E. senegalensis from Côte d'Ivoire.
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