染色质-转录界面:永葆青春的秘密?

IF 7.1 1区医学 Q1 CELL BIOLOGY

Aging Cell Pub Date : 2023-07-10 DOI:10.1111/acel.13927

José M. Izquierdo

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引用次数: 0

摘要

deb等人最近在《自然》杂志上发表的研究报告称，在四种后生动物、两种人类细胞系和人类血液中，RNA聚合酶II (Pol II)介导的转录延伸速度增加与衰老过程中染色质重塑相关。他们的发现可能有助于我们理解为什么我们会通过进化保守的基本过程衰老，并为影响健康寿命、寿命和/或长寿的分子和生理机制打开一扇窗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Chromatin-transcription interface: The secret of eternal youth?

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Chromatin-transcription interface: The secret of eternal youth?

In their recent study in Nature, Debès et al. report an increase in RNA polymerase II (Pol II)-mediated transcriptional elongation speed associated with chromatin remodeling during aging in four metazoan animals, two human cell lines, and human blood. Their findings might help us understand why we age through evolutionarily conserved essential processes, and open a window to the molecular and physiological mechanisms influencing healthspan, lifespan and/or longevity.

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来源期刊

Aging Cell Biochemistry, Genetics and Molecular Biology-Cell Biology

自引率

2.60%

发文量

212

期刊介绍： Aging Cell is an Open Access journal that focuses on the core aspects of the biology of aging, encompassing the entire spectrum of geroscience. The journal's content is dedicated to publishing research that uncovers the mechanisms behind the aging process and explores the connections between aging and various age-related diseases. This journal aims to provide a comprehensive understanding of the biological underpinnings of aging and its implications for human health. The journal is widely recognized and its content is abstracted and indexed by numerous databases and services, which facilitates its accessibility and impact in the scientific community. These include: Academic Search (EBSCO Publishing) Academic Search Alumni Edition (EBSCO Publishing) Academic Search Premier (EBSCO Publishing) Biological Science Database (ProQuest) CAS: Chemical Abstracts Service (ACS) Embase (Elsevier) InfoTrac (GALE Cengage) Ingenta Select ISI Alerting Services Journal Citation Reports/Science Edition (Clarivate Analytics) MEDLINE/PubMed (NLM) Natural Science Collection (ProQuest) PubMed Dietary Supplement Subset (NLM) Science Citation Index Expanded (Clarivate Analytics) SciTech Premium Collection (ProQuest) Web of Science (Clarivate Analytics) Being indexed in these databases ensures that the research published in Aging Cell is discoverable by researchers, clinicians, and other professionals interested in the field of aging and its associated health issues. This broad coverage helps to disseminate the journal's findings and contributes to the advancement of knowledge in geroscience.