前瞻性证据表明,HIV脂肪萎缩和内脏肥胖是部分独立的过程

IF 1.4 Q4 MEDICINE, RESEARCH & EXPERIMENTAL
H. Wand, D. Carey, A. Calmy, M. Law, D. Cooper, S. Emery, A. Carr
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引用次数: 0

摘要

通讯:澳大利亚新南威尔士州悉尼新南威尔士州2052新南威尔士大学Handan Wand国家艾滋病流行病学和临床研究中心电话+61 2 9385 0900传真+61 2 9385 0910邮箱hwand@nchecr.unsw.edu.au目的:研究客观评估的身体成分参数的变化模式,并确定观察到的模式与人类免疫缺陷病毒(HIV)感染的脂肪萎缩成人脂肪营养不良的可修改变量和潜在危险因素的关联程度。方法:使用线性和逻辑回归模型研究肢体脂肪和内脏脂肪组织(VAT)从基线的变化及其与抗逆转录病毒治疗、身体组成和代谢变量的关系。结果:肢体脂肪的增加与较高的基线肢体脂肪(P, 0.0001)、VAT (P = 0.023)以及从基线到第72周的VAT变化(P, 0.0001)显著相关。研究中使用齐多夫定或司他夫定与肢体脂肪增加呈负相关(P = 0.017)。高基线肢体脂肪量和VAT在第72周对随后的VAT增加有负面影响(P = 0.016和P = 0.001)。结论:这项大型前瞻性研究在基线时患有中度或重度脂肪萎缩的hiv感染成人中显示,72周内肢体脂肪变化与VAT呈正相关。这两种脂肪营养不良的危险因素是不同的。我们的研究结果表明,脂肪萎缩和脂肪积累至少是部分独立的过程。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Prospective evidence that HIV lipoatrophy and visceral adiposity are partially independent processes
Correspondence: Handan Wand national Centre in HiV Epidemiology and Clinical research, University of new South Wales, Sydney, nSW 2052, Australia Tel +61 2 9385 0900 Fax +61 2 9385 0910 Email hwand@nchecr.unsw.edu.au Purpose: To investigate the patterns of change in objectively assessed body composition parameters and to determine to what extent the observed patterns correlate with modifiable variables and potential risk factors for lipodystrophy in human immunodeficiency virus (HIV)-infected lipoatrophic adults. Method: Changes from baseline in limb fat and visceral adipose tissue (VAT), and their associations with antiretroviral therapy, body composition, and metabolic variables were investigated using linear and logistic regression models. Results: Increases in limb fat were significantly associated with higher baseline limb fat (P , 0.0001), VAT (P = 0.023), and change from baseline to week 72 in VAT (P , 0.0001). On-study use of zidovudine or stavudine was negatively associated with a limb fat increase (P = 0.017). High baseline limb fat mass and VAT had negative effects on subsequent VAT increases at week 72 (P = 0.016 and P = 0.001, respectively). Conclusions: This large, prospective study in HIV-infected adults with moderate or severe lipoatrophy at baseline showed positive associations between changes in limb fat and VAT over 72 weeks. Risk factors for these two lipodystrophic features were different. Our findings suggest that lipoatrophy and fat accumulation are at least partially independent processes.
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来源期刊
Open Access Journal of Clinical Trials
Open Access Journal of Clinical Trials MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
3.90
自引率
0.00%
发文量
2
审稿时长
16 weeks
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