利用阴离子线性球状树突状分子制备白桦酸减毒增效纳米制剂

IF 1.4 Q4 NANOSCIENCE & NANOTECHNOLOGY

Journal of Nanostructures Pub Date : 2021-01-01 DOI:10.22052/JNS.2021.01.016

Tahereh Zadeh Mehrizi, N. Mosaffa, A. Khamesipour, M. Hoseini, H. E. Shahmabadi, M. Ardestani, Amitis Ramezani

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引用次数: 0

摘要

白桦酸是一种低溶解度、高毒性的抗利什曼病中草药。据我们所知，这是第一个将白桦酸加载到阴离子线性球状树突(ALGD)中以解决毒性和不溶性问题的研究。为了解决上述问题，将BA加载到ALGD纳米载体中。采用傅里叶变换红外光谱(FTIR)、原子力显微镜(AFM)和质子核磁共振(1HNMR)等方法对配方进行了化学键和形貌表征。根据我们的研究，不溶性BA可以很好地装载到ALGD中。这种负荷使BA的溶解度提高了700多倍，在体内环境中毒性效应降至零。总体而言，40 mg/kg剂量的双酚d在体外和体内均能显著减少利什曼原虫(leishmania major, L. major)的数量，但未引起任何毒性作用。

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A Novel Nanoformulation for Reducing the Toxicity and Increasing the Efficacy of Betulinic Acid Using Anionic Linear Globular Dendrimer

Betulinic acid (BA) is an antileishmanial herbal drug with low solubility and high toxicity. To our knowledge, this is the first study in which betulinic acid is loaded into Anionic Linear Globular Dendrimer (ALGD) in order to resolve the toxicity and insolubility problem. In order to solve mentioned problems, BA was loaded into ALGD nanocarrier. The formulation was characterized in terms of chemical bonds and morphology using Fourier Transform Infrared (FTIR) Spectroscopy, Atomic Force Microscopy (AFM) and Proton Nuclear Magnetic Resonance (1HNMR) methods. According to our study insoluble BA could loaded well into ALGD. This loading caused an increase in the solubility rate of BA by more than 700-fold and a decrease in the toxicity effects to zero in vivo environment. Overall, BD at a dose of 40 mg/kg caused a significant decreased in the number of parasite (leishmania major (L. major)) in vitro and in vivo without inducing any toxic effect.

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来源期刊

Journal of Nanostructures NANOSCIENCE & NANOTECHNOLOGY-

CiteScore

2.60

自引率

0.00%

发文量

审稿时长

7 weeks

期刊介绍： Journal of Nanostructures is a medium for global academics to exchange and disseminate their knowledge as well as the latest discoveries and advances in the science and engineering of nanostructured materials. Topics covered in the journal include, but are not limited to the following: Nanosystems for solar cell, energy, catalytic and environmental applications Quantum dots, nanocrystalline materials, nanoparticles, nanocomposites Characterization of nanostructures and size dependent properties Fullerenes, carbon nanotubes and graphene Self-assembly and molecular organization Super hydrophobic surface and material Synthesis of nanostructured materials Nanobiotechnology and nanomedicine Functionalization of nanostructures Nanomagnetics Nanosensors.