弥散张量成像在高级别胶质瘤和脑转移分化中的衍生指标

Q4 Medicine
Alma Brakus, J. Ostojić, M. Lucic
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引用次数: 0

摘要

背景:胶质母细胞瘤和转移瘤的前处理鉴别是神经外科实践中经常遇到的难题。为了精确规划切除或放射治疗,以及确定进一步的诊断程序,需要区分。形态学和光谱成像特征不具体,经常重叠。磁共振成像和磁共振波谱的这一局限性是开展本研究的原因。本研究的目的是确定扩散张量成像指标数据集是否包含可用于区分原发性和继发性轴内肿瘤的信息。方法:在标准磁共振成像(1.5 T系统)上测量81例扩张性、环状增强、轴内病变患者的两个弥散张量成像参数。所有肿瘤组织学证实为胶质母细胞瘤或继发性沉积。为了进行定性分析,定义了两个感兴趣的区域:肿瘤内和邻近肿瘤周围区域(分别为位置1和2)。比较两组的分数各向异性和平均扩散系数值。进行额外的检验以确定两个位置之间的平均值是否存在显著差异。结果:两部位各向异性分数值差异有统计学意义,肿瘤浸润方向各向异性分数值减小,但继发性肿瘤组各向异性分数值无统计学差异。平均扩散系数值似乎无助于区分这两个实体。在两组中,无论是在肿瘤内还是肿瘤周围位置,平均弥散率值都没有显著差异。结论:我们的研究结果证明了将扩散张量成像技术与常规形态学磁共振成像相结合,作为区分原发性和继发性轴内病变的额外诊断工具。定量分析扩散张量成像指标,特别是测量肿瘤周围水肿的分数各向异性有助于准确诊断。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Diffusion tensor imaging derived metrics in high grade glioma and brain metastasis differentiation
Background: Pretreatment differentiation between glioblastoma and metastasis is a frequently encountered dilemma in neurosurgical practice. Distinction is required for precise planning of resection or radiotherapy, and also for defining further diagnostic procedures. Morphology and spectroscopy imaging features are not specific and frequently overlap. This limitation of magnetic resonance imaging and magnetic resonance spectroscopy was the reason to initiate this study. The aim of the present study was to determine whether the dataset of diffusion tensor imaging metrics contains information which may be used for the distinction between primary and secondary intra-axial neoplasms. Methods: Two diffusion tensor imaging parameters were measured in 81 patients with an expansive, ring-enhancing, intra-axial lesion on standard magnetic resonance imaging (1.5 T system). All tumors were histologically verified glioblastoma or secondary deposit. For qualitative analysis, two regions of interest were defined: intratumoral and immediate peritumoral region (locations 1 and 2, respectively). Fractional anisotropy and mean difusivity values of both groups were compared. Additional test was performed to determine if there was a significant difference in mean values between two locations. Results: A statistically significant difference was found in fractional anisotropy values among two locations, with decreasing values in the direction of neoplastic infiltration, although such difference was not observed in fractional anisotropy values in the group with secondary tumors. Mean difusivity values did not appear helpful in differentiation between these two entities. In both groups there was no significant difference in mean difusivity values, neither in intratumoral nor in peritumoral location. Conclusion: The results of our study justify associating the diffusion tensor imaging technique to conventional morphologic magnetic resonance imaging as an additional diagnostic tool for the distinction between primary and secondary intra-axial lesions. Quantitative analysis of diffusion tensor imaging metric, in particular measurement of fractional anisotropy in peritumoral edema facilitates accurate diagnosis.
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来源期刊
Archive of Oncology
Archive of Oncology Medicine-Oncology
CiteScore
0.60
自引率
0.00%
发文量
5
审稿时长
12 weeks
期刊介绍: Archive of Oncology is an international oncology journal that publishes original research, editorials, review articles, case (clinical) reports, and news from oncology (medical, surgical, radiation), experimental oncology, cancer epidemiology, and prevention. Letters are also welcomed. Archive of Oncology is covered by Biomedicina Vojvodina, Biomedicina Serbica, Biomedicina Oncologica, EMBASE/Excerpta Medica, ExtraMED and SCOPUS.
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