治疗前中性粒细胞-淋巴细胞比率和单核细胞-淋巴细胞比率为弥漫性大b细胞淋巴瘤的反应、存活和复发提供线索

Q4 Medicine
B. Demir, I. Serin, DoguMehmet Hilmi
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引用次数: 0

摘要

背景:弥漫性大B细胞淋巴瘤是一种异质性肿瘤组,由大的和转化的B细胞组成,占所有非霍奇金淋巴瘤的30-40%。大量研究指出,初始参数和治疗后反应可作为预后因素。我们的目的是通过中性粒细胞-淋巴细胞和单核细胞-淋巴细胞比率来研究诊断、临床和实验室参数、治疗反应和生存之间的关系。方法:将2009年1月至2019年1月在我院血液科门诊随访的80例患者纳入回顾性分析。结果:中性粒细胞/淋巴细胞比值中位数为3.5(0.3 ~ 50.2),单核细胞/淋巴细胞比值中位数为0.3(0.1 ~ 4.8)。中性粒细胞/淋巴细胞比值组?与> 3.5值组相比,3.5值组有效率显著降低,出勤率和肿块存在率显著升高(p < 0.05)。单核-淋巴细胞比例组?0.30时,退出率显著高于< 0.30组(p < 0.05)。结论:在中性粒细胞-淋巴细胞比率和单核细胞-淋巴细胞比率切断以上的人群中,有统计学意义的大块肿块存在。虽然单独使用这些参数并不充分,但这些参数可以与当前的评分系统结合使用作为预后因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Pre-treatment neutrophil-lymphocyte and monocyte-lymphocyte ratios give clues about response, survival, and recurrence in diffuse large B-cell lymphoma
Background: Diffuse large B cell lymphoma is a heterogeneous tumor group consisting of large and transformed B cells that makeup 30-40% of all non-Hodgkin lymphoma. Numerous studies point out that initial parameters and post-treatment responses can be used as prognostic factors. We aimed to examine the relationship between diagnosis, clinical and laboratory parameters, treatment response and survival using neutrophil-lymphocyte and monocyte-lymphocyte ratios. Methods: A total of 80 patients, followed in our hematology clinic between January 2009-2019, were included in the study and were analyzed retrospectively. Results: The median value of neutrophil- lymphocyte ratio was 3.5 (0.3-50.2) and of monocyte/lymphocyte ratio was 0.3 (0.1-4.8). In the group with neutrophil-lymphocyte ratio ? 3.5 response rates was significantly lower and exitus rate and the bulky mass presence were significantly higher compared to the group with > 3.5 values (p < 0.05). In the group with monocyte-lymphocyte ratio ? 0.30, the exitus rate was significantly higher compared to group with < 0.30 values (p < 0.05). Conclusion: A statistically significant bulky mass presence was demonstrated in the population above the neutrophil-lymphocyte ratio and monocyte-lymphocyte ratio cut off. Although not considered to be sufficient alone, these parameters could be used as prognostic factors in combination with current scoring systems.
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来源期刊
Archive of Oncology
Archive of Oncology Medicine-Oncology
CiteScore
0.60
自引率
0.00%
发文量
5
审稿时长
12 weeks
期刊介绍: Archive of Oncology is an international oncology journal that publishes original research, editorials, review articles, case (clinical) reports, and news from oncology (medical, surgical, radiation), experimental oncology, cancer epidemiology, and prevention. Letters are also welcomed. Archive of Oncology is covered by Biomedicina Vojvodina, Biomedicina Serbica, Biomedicina Oncologica, EMBASE/Excerpta Medica, ExtraMED and SCOPUS.
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