rs2682818/miR-618是伊朗人群中与乳腺癌风险增加相关的新标志物

IF 0.7 4区生物学 Q4 BIOLOGY

Archives of Biological Sciences Pub Date : 2021-01-01 DOI:10.2298/abs210808039n

Atefeh Najafian-Najafabady, Nasim Ebrahimi, Sadeq Vallian

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引用次数: 1

摘要

在微rna (miRNA)编码基因的编码区存在单核苷酸变异，在这些分子在肿瘤发生和癌症中的表达和功能中起着重要作用。在伊朗人群中研究了miR-618中rs2682818与乳腺癌风险增加的关系。采用扩增-难解突变系统PCR (ARMS-PCR)对200名健康个体和乳腺癌患者进行rs2682818/miR-618基因分型。数据显示该标记存在Hardy-Weinberg平衡(HWE)。在健康人群中，等位基因C和A的频率分别为70%和30%;在乳腺癌患者中，等位基因C和A的频率分别为44%和56%。奇比分析显示，rs2682818/miR-618多态性与乳腺癌发生概率增加相关，且具有统计学意义(OR=2.97, P=0.0003)。这些数据表明，rs2682818/miR-618可以被认为是乳腺癌风险增加的新标志物。

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rs2682818/miR-618 is a novel marker associated with increased risk of breast cancer in the Iranian population

The presence of single nucleotide variations in the coding region of micro-RNA (miRNA)- encoding genes plays a significant role in the expression and function of these molecules in oncogenesis and cancer. The association of rs2682818 in miR-618 with increased risk of breast cancer was investigated in the Iranian population. rs2682818/miR-618 was genotyped using amplification-refractory mutation system PCR (ARMS-PCR) in 200 healthy individuals and patients with breast cancer. The data revealed the presence of Hardy-Weinberg equilibrium (HWE) for this marker. The frequency of alleles C and A was 70% and 30%, respectively, in healthy individuals; the frequency of alleles C and A was 44% and 56%, respectively, in patients with breast cancer. Analysis of odd ratios showed that the rs2682818/miR-618 polymorphism is associated with increased probability of breast cancer and is statistically significant (OR=2.97, P=0.0003). The data suggest that rs2682818/miR-618 could be considered a novel marker of increased risk of breast cancer.

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来源期刊

Archives of Biological Sciences 生物-生物学

CiteScore

1.40

自引率

0.00%

发文量

审稿时长

3-8 weeks

期刊介绍： The Archives of Biological Sciences is a multidisciplinary journal that covers original research in a wide range of subjects in life science, including biology, ecology, human biology and biomedical research. The Archives of Biological Sciences features articles in genetics, botany and zoology (including higher and lower terrestrial and aquatic plants and animals, prokaryote biology, algology, mycology, entomology, etc.); biological systematics; evolution; biochemistry, molecular and cell biology, including all aspects of normal cell functioning, from embryonic to differentiated tissues and in different pathological states; physiology, including chronobiology, thermal biology, cryobiology; radiobiology; neurobiology; immunology, including human immunology; human biology, including the biological basis of specific human pathologies and disease management.