rs2682818/miR-618是伊朗人群中与乳腺癌风险增加相关的新标志物

Pub Date : 2021-01-01 DOI:10.2298/abs210808039n

Atefeh Najafian-Najafabady, Nasim Ebrahimi, Sadeq Vallian

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引用次数: 1

摘要

在微rna (miRNA)编码基因的编码区存在单核苷酸变异，在这些分子在肿瘤发生和癌症中的表达和功能中起着重要作用。在伊朗人群中研究了miR-618中rs2682818与乳腺癌风险增加的关系。采用扩增-难解突变系统PCR (ARMS-PCR)对200名健康个体和乳腺癌患者进行rs2682818/miR-618基因分型。数据显示该标记存在Hardy-Weinberg平衡(HWE)。在健康人群中，等位基因C和A的频率分别为70%和30%;在乳腺癌患者中，等位基因C和A的频率分别为44%和56%。奇比分析显示，rs2682818/miR-618多态性与乳腺癌发生概率增加相关，且具有统计学意义(OR=2.97, P=0.0003)。这些数据表明，rs2682818/miR-618可以被认为是乳腺癌风险增加的新标志物。

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rs2682818/miR-618 is a novel marker associated with increased risk of breast cancer in the Iranian population

The presence of single nucleotide variations in the coding region of micro-RNA (miRNA)- encoding genes plays a significant role in the expression and function of these molecules in oncogenesis and cancer. The association of rs2682818 in miR-618 with increased risk of breast cancer was investigated in the Iranian population. rs2682818/miR-618 was genotyped using amplification-refractory mutation system PCR (ARMS-PCR) in 200 healthy individuals and patients with breast cancer. The data revealed the presence of Hardy-Weinberg equilibrium (HWE) for this marker. The frequency of alleles C and A was 70% and 30%, respectively, in healthy individuals; the frequency of alleles C and A was 44% and 56%, respectively, in patients with breast cancer. Analysis of odd ratios showed that the rs2682818/miR-618 polymorphism is associated with increased probability of breast cancer and is statistically significant (OR=2.97, P=0.0003). The data suggest that rs2682818/miR-618 could be considered a novel marker of increased risk of breast cancer.

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