自噬是治疗结核病最重要的策略之一本文着重

M. Youssefi, M. Eslami, M. Karbalaei, M. Keikha, K. Ghazvini
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引用次数: 3

摘要

癌症被定义为不受控制的细胞分裂,它可以扩散或侵入各种组织。癌症有200多种,包括乳腺癌、皮肤癌、肺癌、结肠癌、前列腺癌和淋巴瘤,其症状和适应症因组织类型而异。癌症有几种不同用途的治疗方法。例如,化疗、放射治疗、手术或它们的联合治疗是癌症的常用治疗方式。然而,完全治愈癌症的方法尚未实现。另一方面,由于癌细胞对化疗药物产生耐药性的能力,用于癌症治疗的新药效率不高。最近,有报道称天然化合物可以提高癌症治疗的效率。多不饱和脂肪酸(PUFAs)是一种天然化合物,可以作为癌症患者的膳食补充剂。pufa主要分为两类,包括n-3和n-6 pufa。文献表明,n-3 PUFAs通过诱导凋亡通路、抑制细胞增殖发挥抗癌保护作用,而n-6 PUFAs通过诱导细胞生长和增殖产生肿瘤。PUFAs与化疗药物联合使用被认为是通过增加癌细胞死亡来治疗癌症患者的有效方法。本文旨在讨论PUFAs的结构和功能通过各种信号通路对癌症和细胞过程的相互作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Autophagy as one of the most important strategies for the treatment of tuberculosis; Mini-review
Cancer is defined as uncontrolled cell division, which could spread or invade various tissues. There are more than 200 types of cancer, including breast, skin, lung, colon, and prostate cancer, and lymphoma, the symptoms and indications of which vary depending on the type of tissues. Cancer has several treatments with different applications. For instance, chemotherapy, radiation therapy, surgery or their combination are common treatment modalities for cancer. However, a complete cure for cancer has not been achieved yet. On the other hand, novel drugs for cancer treatment are not efficient due to the ability of cancer cells to develop resistance against chemotherapeutic agents. Recently, natural compounds have been reported to improve the efficiency of cancer treatment. Polyunsaturated fatty acids (PUFAs) are natural compounds that could be used as dietary supplements in cancer patients. PUFAs are classified into two main categories, including n-3 and n-6 PUFAs. According to the literature, n-3 PUFAs exert protective effects against cancer through the induction of apoptotic pathways and suppressing cell proliferation, while n-6 PUFAs cause tumor formation by inducing cell growth and proliferation. Using PUFAs in combination with chemotherapeutic agents is considered to be an effective approach to the treatment of cancer patients through increasing cancer cell death. This review aimed to discuss the interactive effects of the structure and function of PUFAs on cancer and cell processes through various signaling pathways.
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