含盐酸心得安脂质体的热负责pluronic F- 127水凝胶的制备及体外眼给药

IF 1.4 Q4 NANOSCIENCE & NANOTECHNOLOGY
B. Makhmalzadeh, M. Radpey, M. Abbaspour
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引用次数: 1

摘要

目的:眼药水的生物利用度较差主要是由于鼻泪引流迅速和角膜上皮的不渗透性。本研究的主要目的是制备一种脂质体水凝胶,用于盐酸心得安作为β阻断剂药物的眼部递送,以提高药物在所需作用部位的浓度。材料与方法:本研究采用均质法和薄层法设计并制备脂质体,并将其分散到pluronic基水凝胶中。将优化后的脂质体和脂质体水凝胶用于兔眼离体眼透性研究。结果:脂质体粒径为170 ~ 380 nm,包封率为34 ~ 65%,24 h后载药的缓释率为30 ~ 60%,脂质体在水凝胶中分散,缓释率较低。脂质体和脂质体水凝胶使眼生物利用度提高3倍以上。结论:在本研究中,热致因子(pluronic)的使用导致药物在体温下形成凝胶结构,从而延长了剂型在眼内的耐药时间。因此,一个由pluronic factor和脂质体组成的系统将是非常有趣的,因为它将配对pluronic factor的热凝胶特性和脂质体制剂的载体特性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Preparation and Ex-vivo Ocular delivery of Thermo-responsible pluronic F- 127 hydrogel containing Propranolol hydrochloride- loaded Liposomes
Objective(s): Poor bioavailability of ophthalmic drops is mainly due to rapid nasolacrimal drainage and eye impermeability of corneal epithelium. The main aim of this study is to prepare a liposomal hydrogel for the ocular delivery of propranolol hydrochloride as a β-blocker drug to enhance drug concentration at the desired site of action.Materials and Methods: In this study liposome formulations were designed and prepared by homogenization and thin-layer methods and then dispersed into the pluronic based hydrogel. The optimized liposomes and liposomal hydrogel were used in Ex-vivo ocular permeation studies through the rabbit’s eye.Results: liposomes showed 170-380 nm particle size, 34-65% entrapment efficiency, and sustained release profiles that 30-60 % of loaded drug released after 24 h. liposomes dispersed in hydrogels demonstrated a lower release rate. Liposomes and liposomal hydrogel increased ocular bioavailability of more than 3-folds. Conclusion: In this study, the administration of thermo-responsible factors (pluronic) led to longer resistance time of the dosage form in the eye because the drug would turn into gel structures at the body temperature. Therefore, a system consisting of both pluronic factor and liposomes will be of great interest because it will pair up the Thermo gelling properties of the pluronic factor and the carrier characteristics of the liposome formulations.
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来源期刊
Nanomedicine Journal
Nanomedicine Journal NANOSCIENCE & NANOTECHNOLOGY-
CiteScore
3.40
自引率
0.00%
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0
审稿时长
12 weeks
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