含盐酸心得安脂质体的热负责pluronic F- 127水凝胶的制备及体外眼给药

IF 1.4 Q4 NANOSCIENCE & NANOTECHNOLOGY
B. Makhmalzadeh, M. Radpey, M. Abbaspour
{"title":"含盐酸心得安脂质体的热负责pluronic F- 127水凝胶的制备及体外眼给药","authors":"B. Makhmalzadeh, M. Radpey, M. Abbaspour","doi":"10.22038/NMJ.2021.08.09","DOIUrl":null,"url":null,"abstract":"Objective(s): Poor bioavailability of ophthalmic drops is mainly due to rapid nasolacrimal drainage and eye impermeability of corneal epithelium. The main aim of this study is to prepare a liposomal hydrogel for the ocular delivery of propranolol hydrochloride as a β-blocker drug to enhance drug concentration at the desired site of action.Materials and Methods: In this study liposome formulations were designed and prepared by homogenization and thin-layer methods and then dispersed into the pluronic based hydrogel. The optimized liposomes and liposomal hydrogel were used in Ex-vivo ocular permeation studies through the rabbit’s eye.Results: liposomes showed 170-380 nm particle size, 34-65% entrapment efficiency, and sustained release profiles that 30-60 % of loaded drug released after 24 h. liposomes dispersed in hydrogels demonstrated a lower release rate. Liposomes and liposomal hydrogel increased ocular bioavailability of more than 3-folds. Conclusion: In this study, the administration of thermo-responsible factors (pluronic) led to longer resistance time of the dosage form in the eye because the drug would turn into gel structures at the body temperature. Therefore, a system consisting of both pluronic factor and liposomes will be of great interest because it will pair up the Thermo gelling properties of the pluronic factor and the carrier characteristics of the liposome formulations.","PeriodicalId":18933,"journal":{"name":"Nanomedicine Journal","volume":"8 1","pages":"80-88"},"PeriodicalIF":1.4000,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Preparation and Ex-vivo Ocular delivery of Thermo-responsible pluronic F- 127 hydrogel containing Propranolol hydrochloride- loaded Liposomes\",\"authors\":\"B. Makhmalzadeh, M. Radpey, M. Abbaspour\",\"doi\":\"10.22038/NMJ.2021.08.09\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objective(s): Poor bioavailability of ophthalmic drops is mainly due to rapid nasolacrimal drainage and eye impermeability of corneal epithelium. The main aim of this study is to prepare a liposomal hydrogel for the ocular delivery of propranolol hydrochloride as a β-blocker drug to enhance drug concentration at the desired site of action.Materials and Methods: In this study liposome formulations were designed and prepared by homogenization and thin-layer methods and then dispersed into the pluronic based hydrogel. The optimized liposomes and liposomal hydrogel were used in Ex-vivo ocular permeation studies through the rabbit’s eye.Results: liposomes showed 170-380 nm particle size, 34-65% entrapment efficiency, and sustained release profiles that 30-60 % of loaded drug released after 24 h. liposomes dispersed in hydrogels demonstrated a lower release rate. Liposomes and liposomal hydrogel increased ocular bioavailability of more than 3-folds. Conclusion: In this study, the administration of thermo-responsible factors (pluronic) led to longer resistance time of the dosage form in the eye because the drug would turn into gel structures at the body temperature. Therefore, a system consisting of both pluronic factor and liposomes will be of great interest because it will pair up the Thermo gelling properties of the pluronic factor and the carrier characteristics of the liposome formulations.\",\"PeriodicalId\":18933,\"journal\":{\"name\":\"Nanomedicine Journal\",\"volume\":\"8 1\",\"pages\":\"80-88\"},\"PeriodicalIF\":1.4000,\"publicationDate\":\"2021-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nanomedicine Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.22038/NMJ.2021.08.09\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"NANOSCIENCE & NANOTECHNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nanomedicine Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.22038/NMJ.2021.08.09","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"NANOSCIENCE & NANOTECHNOLOGY","Score":null,"Total":0}
引用次数: 1

摘要

目的:眼药水的生物利用度较差主要是由于鼻泪引流迅速和角膜上皮的不渗透性。本研究的主要目的是制备一种脂质体水凝胶,用于盐酸心得安作为β阻断剂药物的眼部递送,以提高药物在所需作用部位的浓度。材料与方法:本研究采用均质法和薄层法设计并制备脂质体,并将其分散到pluronic基水凝胶中。将优化后的脂质体和脂质体水凝胶用于兔眼离体眼透性研究。结果:脂质体粒径为170 ~ 380 nm,包封率为34 ~ 65%,24 h后载药的缓释率为30 ~ 60%,脂质体在水凝胶中分散,缓释率较低。脂质体和脂质体水凝胶使眼生物利用度提高3倍以上。结论:在本研究中,热致因子(pluronic)的使用导致药物在体温下形成凝胶结构,从而延长了剂型在眼内的耐药时间。因此,一个由pluronic factor和脂质体组成的系统将是非常有趣的,因为它将配对pluronic factor的热凝胶特性和脂质体制剂的载体特性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Preparation and Ex-vivo Ocular delivery of Thermo-responsible pluronic F- 127 hydrogel containing Propranolol hydrochloride- loaded Liposomes
Objective(s): Poor bioavailability of ophthalmic drops is mainly due to rapid nasolacrimal drainage and eye impermeability of corneal epithelium. The main aim of this study is to prepare a liposomal hydrogel for the ocular delivery of propranolol hydrochloride as a β-blocker drug to enhance drug concentration at the desired site of action.Materials and Methods: In this study liposome formulations were designed and prepared by homogenization and thin-layer methods and then dispersed into the pluronic based hydrogel. The optimized liposomes and liposomal hydrogel were used in Ex-vivo ocular permeation studies through the rabbit’s eye.Results: liposomes showed 170-380 nm particle size, 34-65% entrapment efficiency, and sustained release profiles that 30-60 % of loaded drug released after 24 h. liposomes dispersed in hydrogels demonstrated a lower release rate. Liposomes and liposomal hydrogel increased ocular bioavailability of more than 3-folds. Conclusion: In this study, the administration of thermo-responsible factors (pluronic) led to longer resistance time of the dosage form in the eye because the drug would turn into gel structures at the body temperature. Therefore, a system consisting of both pluronic factor and liposomes will be of great interest because it will pair up the Thermo gelling properties of the pluronic factor and the carrier characteristics of the liposome formulations.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Nanomedicine Journal
Nanomedicine Journal NANOSCIENCE & NANOTECHNOLOGY-
CiteScore
3.40
自引率
0.00%
发文量
0
审稿时长
12 weeks
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信