基于纳米粒子的放射治疗在纳米尺度上的物理剂量增强分析:一个簇和内皮细胞模型

IF 1.4 Q4 NANOSCIENCE & NANOTECHNOLOGY
E. Mansouri, A. Mesbahi, Parivar Yazdani
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引用次数: 5

摘要

目的:传统放射治疗的一个主要困难是肿瘤和危险器官之间缺乏选择性。在纳米粒子辅助放射治疗中,重元素在肿瘤中的浓度高于正常组织。本研究旨在模拟由金、钆、铱、铋和铪原子组成的五种不同纳米粒子团簇与低能x射线(能量类似于近距离治疗源)相互作用产生的二次电子的特征,作为纳米粒子大小和光束能量的函数。材料和方法:为了更好地评估二次电子在能量沉积中的贡献,并为未来进一步的测量分析建立一个框架,我们试图通过纳米粒子增强放疗来增强和促进内皮细胞能量沉积的现有数学模型。同时,利用MCNPX蒙特卡罗程序对相同几何形状的纳米团簇进行了模拟,并计算了不同类型纳米团簇的剂量增强因子。结果:我们的研究结果表明,对于由纳米团簇和内皮细胞组成的模型,DEF显著取决于光子的能量以及纳米团簇内原子的L边和k边结合能。然而,对于能量为60kev的Gd,可以看到更高的剂量增强因子。结论:该数学模型考虑了DEF随光子能量的变化,并且在DEF计算中考虑了NP类型的影响。然而,与数学方法相比,MC方法对光子能量具有很高的灵敏度和NP型。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Analysis of physical dose enhancement in nano-scale for nanoparticle-based radiation therapy: a Cluster and endothelial cell model
Objective(s): One major difficulty of conventional radiotherapy is the lack of selectivity between the tumor and the organs at risk. In nanoparticle aided radiotherapy, heavy elements are present at higher concentrations in the tumor than normal tissues. This study aimed to model the characteristics of secondary electrons generated from the interaction of clusters comprised of five different nanoparticles including Gold, Gadolinium, Iridium, Bismuth, and Hafnium atoms with low energy x-rays (similar to brachytherapy sources in terms of energy) as a function of nanoparticle size and beam energy. Materials and Methods: To better evaluate the contributions of secondary electrons in energy deposition, and also to develop a framework in analyzing further measurements in the future, we attempted to enhance and promote existing mathematical models for energy deposition in endothelial cells by nanoparticle-enhanced radiotherapy. Also, the MCNPX Monte Carlo code was used to model the identical geometry and the dose enhancement factor was calculated for all types of simulated nano-clusters.Results: Our results showed that for our model consist of a nano-cluster and an endothelial cell the DEF significantly depends on the energy of photons and L- and K-edge binding energy of the atoms inside the nano-cluster. However, for Gd at the energy 60 keV, a higher dose enhancement factor was seen.Conclusion: It can be concluded that the mathematical model considers the DEF variation with photon energy and the effect of NP type is considered in DEF calculations. However, the MC method has indicated very high sensitivity to photon energy, and NP type compared to the mathematical method.
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来源期刊
Nanomedicine Journal
Nanomedicine Journal NANOSCIENCE & NANOTECHNOLOGY-
CiteScore
3.40
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