慢性淋巴细胞白血病间期FISH检测染色体异常的发生率

International Journal of Hematologic Oncology Pub Date : 2015-11-23 DOI:10.2217/IJH.15.19

M. Braekeleer, M. L. Bris, A. Basinko, F. Morel, N. Douet-Guilbert

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引用次数: 2

摘要

目的与方法:采用间期FISH检测638例b细胞慢性淋巴细胞白血病患者的染色体改变发生率。结果:75%的患者出现染色体异常。在诊断和随访期间，分别有57.3%和57%的患者存在Del(13)(q14)。其次是12三体(诊断时和随访期间分别为19.8%和19.8%)，del(11)(q22)(诊断时和随访期间分别为9.1和14.3%)和del(17)(p13)(诊断时和随访期间分别为2.8和12.4%)。讨论与结论:我们的结果与文献报道的55项研究结果相关。与作为进化标志的del(11)(q22)和del(17)(p13)相反，12三体和del(13)(q14)在诊断时的比例很高，在进展过程中不富集。

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Incidence of chromosomal anomalies detected by interphase FISH in chronic lymphoid leukemia

Aims & methods: We used interphase FISH to determine the incidence of chromosomal changes in 638 B-cell chronic lymphocytic leukemia patients. Results: Chromosomal abnormalities were found in some 75% of the patients. Del(13)(q14) was present in 57.3 and 57% of patients at diagnosis and during follow-up, respectively. It was followed by trisomy 12 (19 and 19.8% at diagnosis and during follow-up, respectively), del(11)(q22) (9.1 and 14.3% at diagnosis and during follow-up, respectively) and del(17)(p13) (2.8 and 12.4% at diagnosis and during follow-up, respectively). Discussion & conclusion: Our results correlate with those obtained in 55 studies reported in the literature. Trisomy 12 and del(13)(q14) are present in high proportions at diagnosis and are not enriched during progression, to the contrary of del(11)(q22) and del(17)(p13) that are markers of evolution.

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来源期刊

International Journal of Hematologic Oncology

自引率

0.00%

发文量

审稿时长

13 weeks

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