造血干细胞移植后白血病和淋巴瘤的定向t细胞治疗:超越嵌合抗原受体

International Journal of Hematologic Oncology Pub Date : 2015-10-12 DOI:10.2217/IJH.15.11

C. Bollard, C. Cruz, A. Barrett

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引用次数: 0

摘要

本文综述了造血干细胞移植后过继性T细胞免疫治疗的最新进展，利用自体移植后的T细胞治疗高危患者。特别强调的是使用T细胞治疗白血病和淋巴瘤，通过基因转移和非基因转移方法直接特异性针对肿瘤相关抗原。在这篇综述中，我们将重点介绍这些新疗法如何成功地用于预防或治疗造血干细胞移植后复发的高危患者。

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Directed T-cell therapies for leukemia and lymphoma after hematopoietic stem cell transplant: beyond chimeric antigen receptors

This review focuses on the recent advances utilizing adoptive T-cell immunotherapies for patients after hematopoietic stem cell transplant using T cells after autologous transplant to treat the highest risk patients. The particular emphasis is the use of T cells to treat leukemias and lymphomas with gene transfer and nongene transfer approaches to direct specificity to tumor associated antigens. In this review, we will highlight how these novel therapeutics can be successfully used to prevent or treat high-risk patients who relapse after hematopoietic stem cell transplant.

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来源期刊

International Journal of Hematologic Oncology

自引率

0.00%

发文量

审稿时长

13 weeks

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