病理学家的观点:诊断嗜铬细胞瘤和副神经节瘤的分子谱

IF 1.2

International Journal of Endocrine Oncology Pub Date : 2015-08-21 DOI:10.2217/IJE.15.16

N. Kimura

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引用次数: 6

摘要

嗜铬细胞瘤(PCC)和副神经节瘤(PGL)是一种产生儿茶酚胺(CA)的肿瘤，根据肾上腺嗜铬细胞瘤和副神经节瘤(GAPP)的分级分为良好(WD)、中度(MD)或低分化(PD)类型。70%的PCCs/ pgl为WD型，4%为转移，其余为MD型，60%为转移，PD型为转移88%。因此，PCCs/ pgl也可分为低级别(WD型)、中级级别(MD型)和高级别恶性肿瘤(PD型)。MD/PD类型有70%的转移。因此，使用GAPP也可以将PCCs/ pgl分为低级别(WD型)和高级别恶性肿瘤(MD/PD型)。遗传性PCCs/ pgl以前根据涉及的基因突变和肿瘤产生的儿茶酚胺的类型被分为1类或2类。GAPP显示集群1和集群2的肿瘤分别对应MD型和WD型。高度恶性肿瘤(PD型)的易感基因目前尚不清楚。

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A pathologist's view: molecular profiles for diagnosing pheochromocytomas and paragangliomas

Pheochromocytomas (PCC) and paragangliomas (PGL) are catecholamine (CA)-producing tumors classified into well (WD)-, moderately (MD)- or poorly differentiated (PD) types by the Grading of Adrenal Pheochromocytoma and Paraganglioma (GAPP). Seventy percent of PCCs/PGLs are WD type with 4% metastasis, the rest are MD with 60% and PD are with 88% metastasis. Thus, PCCs/PGLs can also be classified as low-grade (WD type), intermediate grade (MD type) and high-grade malignancies (PD types). MD/PD types are with 70% metastasis. Thus, PCCs/PGLs can also be classified as low-grade (WD type) and high-grade malignancies (MD/PD types) using GAPP. Hereditary PCCs/PGLs have been previously classified into cluster 1 or cluster 2 based on genetic mutations involved and types of catecholamine produced by the tumors. GAPP revealed that tumors in cluster 1 and cluster 2 correspond to MD type and WD type, respectively. Susceptible genes for high-grade malignancy (PD type) are currently unknown.

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来源期刊

International Journal of Endocrine Oncology ONCOLOGY-

自引率

0.00%

发文量

审稿时长

13 weeks

期刊介绍： International Journal of Endocrine Oncology is a quarterly, peer-reviewed journal that helps the clinician to keep up to date with best practice in this fast-moving field. The journal highlights significant advances in basic and translational research, and places them in context for future therapy. The journal presents the latest research findings in diagnosis and management of endocrine cancer, together with authoritative reviews, cutting-edge editorials and perspectives that highlight hot topics and controversy in the field. Independent drug evaluations assess newly approved medications and their role in clinical practice. The journal welcomes the unsolicited submission of article proposals and original research manuscripts.