肝细胞癌中阿霉素耐药的机制。

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2016-01-01 DOI:10.2217/HEP.15.41

Josiah Cox, S. Weinman

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引用次数: 116

摘要

肝细胞癌是世界上最常见的实体肿瘤之一，对现有的化疗方法反应较差。虽然全身化疗的益处有限，但动脉内给药多柔比星往往能使肿瘤缩小。它的效用有限，部分原因是阿霉素耐药性的频繁出现。这种耐药的机制包括多药耐药外排泵的表达增加、药物靶点、拓扑异构酶的改变和程序性细胞死亡途径的调节。许多这些影响是由miRNA表达的变化引起的，在具有干细胞表型的肿瘤细胞中尤为突出。本文将对肝细胞癌的阿霉素耐药机制和化疗增敏的潜在途径进行综述。

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Mechanisms of doxorubicin resistance in hepatocellular carcinoma.

Hepatocellular carcinoma, one of the most common solid tumors worldwide, is poorly responsive to available chemotherapeutic approaches. While systemic chemotherapy is of limited benefit, intra-arterial delivery of doxorubicin to the tumor frequently produces tumor shrinkage. Its utility is limited, in part, by the frequent emergence of doxorubicin resistance. The mechanisms of this resistance include increased expression of multidrug resistance efflux pumps, alterations of the drug target, topoisomerase, and modulation of programmed cell death pathways. Many of these effects result from changes in miRNA expression and are particularly prominent in tumor cells with a stem cell phenotype. This review will summarize the current knowledge on the mechanisms of doxorubicin resistance of hepatocellular carcinoma and the potential for approaches toward therapeutic chemosensitization.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.