冠心病患者PAI-1基因启动子多态性与血清丝氨酸蛋白酶E1、丙二醛和Hs-CRP水平的关系

IF 0.2 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS

International Cardiovascular Research Journal Pub Date : 2016-09-15 DOI:10.17795/ICRJ-10(03)129

Ansar Karimian, S. Farajnia, M. Ghojazadeh, F. Khaki-Khatibi

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引用次数: 3

摘要

背景:由动脉粥样硬化引起的冠状动脉疾病(CAD)。研究表明，有许多因素与CAD的发生发展密切相关，包括纤溶酶原激活物抑制剂-1(PAI-1)等细胞结合分子、脂质过氧化、炎症和止血。目的:本病例对照研究旨在评估纤溶酶原激活物抑制剂-1 (PAI-1) 4G/5G多态性与氧化应激标志物和冠状动脉疾病(CAD)的关系。可能与其他一些因素相关，如甘油三酯、胆固醇、低密度脂蛋白和高密度脂蛋白水平的升高或降低。PAI-1多态性与其他基因间无显著相关性

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The Association between PAI-1 Gene Promoter Polymorphism and Serum Serpin E1, MDA, and Hs-CRP Levels in Coronary Artery Disease

Background: Coronary artery disease (CAD) caused by atherosclerosis. Studies have shown that there are a number of factors which are closely related to the development and progression of CAD that include Cellular binding molecules like Plasminogen Activator Inhibitor-1(PAI-1), Lipid peroxidation, inflammation and hemostasis. Objectives: The present case-control study aimed to evaluate the association between Plasminogen Activator Inhibitor-1 (PAI-1) 4G/5G polymorphism and oxidative stress markers and Coronary Artery Disease (CAD). might be important in correlation with some other factors, such as increased or decreased triglyceride, cholesterol, and LDL and HDL levels. However, no significant correlation was observed between PAI-1 polymorphism

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来源期刊

International Cardiovascular Research Journal CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

0.40

自引率

50.00%

发文量