成纤维生长因子2和转化生长因子β1在犬软骨细胞软骨组织工程中的序贯应用

The open tissue engineering and regenerative medicine journal Pub Date : 2008-06-13 DOI:10.2174/1875043500801010008

W. Gordon-Evans, M. Yaeger, M. Greenlee, M. Conzemius

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引用次数: 0

摘要

本研究研究了成纤维细胞生长因子2在单层培养和转化生长因子1在三维培养中对软骨细胞基质生成的影响。在所提出的培养条件下，FGF2是有丝分裂的，而不是软骨形成的。此外，TGF 1刺激主要产生I型胶原。

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Sequential Use of Fibroblastic Growth Factor 2 and Transforming Growth Factor β1 in Cartilage Tissue Engineering Using Canine Chondrocytes

This study investigated the effect of fibroblast growth factor 2 in monolayer followed by transforming growth factor 1 in 3-dimensional culture on chondrocytic matrix production. Under the culture conditions presented, FGF2 is mitogenic but not chondrogenic. In addition, TGF 1 stimulation produced predominantly type I collagen.

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The open tissue engineering and regenerative medicine journal

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