{"title":"腺病毒从感染细胞中释放是腺病毒溶瘤的关键因素","authors":"A. Gros, S. Guedan","doi":"10.2174/1875037001003010024","DOIUrl":null,"url":null,"abstract":"Adenovirus release is not triggered until late times after viral infection, when the adenovirus death protein (ADP) accumulates to induce viral egress. Thus, the natural rate of adenovirus release may hinder the spread of oncolytic adenoviruses. Several experimental approaches have provided evidence indicating that promoting adenovirus release can be used to enhance their therapeutic potential. This review briefly summarizes what is known about the mechanism of adenovirus release and describes three different strategies, ADP overexpression, apoptosis induction, and bioselection, which can be used to enhance adenovirus release. Finally we will discuss some of the future perspectives that will contribute to the better use of progeny release for the improvement of the antitumor activity of oncolytic adenoviruses.","PeriodicalId":88328,"journal":{"name":"The open gene therapy journal","volume":"3 1","pages":"24-30"},"PeriodicalIF":0.0000,"publicationDate":"2013-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"12","resultStr":"{\"title\":\"Adenovirus Release from the Infected Cell as a Key Factor for Adenovirus Oncolysis\",\"authors\":\"A. Gros, S. Guedan\",\"doi\":\"10.2174/1875037001003010024\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Adenovirus release is not triggered until late times after viral infection, when the adenovirus death protein (ADP) accumulates to induce viral egress. Thus, the natural rate of adenovirus release may hinder the spread of oncolytic adenoviruses. Several experimental approaches have provided evidence indicating that promoting adenovirus release can be used to enhance their therapeutic potential. This review briefly summarizes what is known about the mechanism of adenovirus release and describes three different strategies, ADP overexpression, apoptosis induction, and bioselection, which can be used to enhance adenovirus release. Finally we will discuss some of the future perspectives that will contribute to the better use of progeny release for the improvement of the antitumor activity of oncolytic adenoviruses.\",\"PeriodicalId\":88328,\"journal\":{\"name\":\"The open gene therapy journal\",\"volume\":\"3 1\",\"pages\":\"24-30\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2013-07-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"12\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The open gene therapy journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2174/1875037001003010024\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The open gene therapy journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1875037001003010024","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Adenovirus Release from the Infected Cell as a Key Factor for Adenovirus Oncolysis
Adenovirus release is not triggered until late times after viral infection, when the adenovirus death protein (ADP) accumulates to induce viral egress. Thus, the natural rate of adenovirus release may hinder the spread of oncolytic adenoviruses. Several experimental approaches have provided evidence indicating that promoting adenovirus release can be used to enhance their therapeutic potential. This review briefly summarizes what is known about the mechanism of adenovirus release and describes three different strategies, ADP overexpression, apoptosis induction, and bioselection, which can be used to enhance adenovirus release. Finally we will discuss some of the future perspectives that will contribute to the better use of progeny release for the improvement of the antitumor activity of oncolytic adenoviruses.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
