{"title":"二甲胺四环素降低大鼠对3,4 -亚甲基二氧甲基苯丙胺(MDMA)的高温反应","authors":"P. Anderson, M. Hutchinson, R. Irvine, A. Salem","doi":"10.2174/1874941001104010004","DOIUrl":null,"url":null,"abstract":"Hyperthermia is a key clinical outcome from recreational use of MDMA and is the leading cause of MDMA related hospital admissions as well as being linked to enhanced neurotoxicity [1, 2]. Animal models of ischemia which also display hyperthermia have shown an inflammatory process mediated by microglia and the release of the proinflammatory cytokine interleukin 1(IL-1 ) play a role in hyperthermicreactions [3]. Previous studies showed that microglia is prominently activated and IL-1 levels increased following MDMA administration [4], lending support to the hypothesis microglia play a role in MDMA induced hyperthermia. Minocycline is a tetracycline antibiotic with powerful anti-inflammatory properties, thought to be a result of its ability to attenuate glial activation [5]. This study examined whether preventing microglial activation through the administration of minocycline could limit or prevent the hyperthermia induced by MDMA.","PeriodicalId":89289,"journal":{"name":"The open addiction journal","volume":"4 1","pages":"4-5"},"PeriodicalIF":0.0000,"publicationDate":"2011-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":"{\"title\":\"Attenuating Glial Activation with Minocycline Reduces the Hyperthermic Response to 3, 4-Methylenedioxymethamphetamine (MDMA) In the Rat\",\"authors\":\"P. Anderson, M. Hutchinson, R. Irvine, A. Salem\",\"doi\":\"10.2174/1874941001104010004\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Hyperthermia is a key clinical outcome from recreational use of MDMA and is the leading cause of MDMA related hospital admissions as well as being linked to enhanced neurotoxicity [1, 2]. Animal models of ischemia which also display hyperthermia have shown an inflammatory process mediated by microglia and the release of the proinflammatory cytokine interleukin 1(IL-1 ) play a role in hyperthermicreactions [3]. Previous studies showed that microglia is prominently activated and IL-1 levels increased following MDMA administration [4], lending support to the hypothesis microglia play a role in MDMA induced hyperthermia. Minocycline is a tetracycline antibiotic with powerful anti-inflammatory properties, thought to be a result of its ability to attenuate glial activation [5]. This study examined whether preventing microglial activation through the administration of minocycline could limit or prevent the hyperthermia induced by MDMA.\",\"PeriodicalId\":89289,\"journal\":{\"name\":\"The open addiction journal\",\"volume\":\"4 1\",\"pages\":\"4-5\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2011-03-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The open addiction journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2174/1874941001104010004\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The open addiction journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1874941001104010004","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Attenuating Glial Activation with Minocycline Reduces the Hyperthermic Response to 3, 4-Methylenedioxymethamphetamine (MDMA) In the Rat
Hyperthermia is a key clinical outcome from recreational use of MDMA and is the leading cause of MDMA related hospital admissions as well as being linked to enhanced neurotoxicity [1, 2]. Animal models of ischemia which also display hyperthermia have shown an inflammatory process mediated by microglia and the release of the proinflammatory cytokine interleukin 1(IL-1 ) play a role in hyperthermicreactions [3]. Previous studies showed that microglia is prominently activated and IL-1 levels increased following MDMA administration [4], lending support to the hypothesis microglia play a role in MDMA induced hyperthermia. Minocycline is a tetracycline antibiotic with powerful anti-inflammatory properties, thought to be a result of its ability to attenuate glial activation [5]. This study examined whether preventing microglial activation through the administration of minocycline could limit or prevent the hyperthermia induced by MDMA.