二甲胺四环素降低大鼠对3,4 -亚甲基二氧甲基苯丙胺(MDMA)的高温反应

P. Anderson, M. Hutchinson, R. Irvine, A. Salem
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引用次数: 3

摘要

高热是娱乐性使用MDMA的一个关键临床结果,是MDMA相关住院的主要原因,并与神经毒性增强有关[1,2]。缺血动物模型显示,小胶质细胞介导的炎症过程和促炎细胞因子白细胞介素1(IL-1)的释放在高温反应[3]中起作用。先前的研究表明,MDMA给药后,小胶质细胞明显被激活,IL-1水平升高,这支持了小胶质细胞在MDMA诱导的热疗中起作用的假设。二甲胺四环素是一种四环素抗生素,具有强大的抗炎特性,被认为是其能够减弱胶质细胞激活的结果。本研究考察了通过二甲胺四环素预防小胶质细胞激活是否可以限制或预防MDMA引起的高热。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Attenuating Glial Activation with Minocycline Reduces the Hyperthermic Response to 3, 4-Methylenedioxymethamphetamine (MDMA) In the Rat
Hyperthermia is a key clinical outcome from recreational use of MDMA and is the leading cause of MDMA related hospital admissions as well as being linked to enhanced neurotoxicity [1, 2]. Animal models of ischemia which also display hyperthermia have shown an inflammatory process mediated by microglia and the release of the proinflammatory cytokine interleukin 1(IL-1 ) play a role in hyperthermicreactions [3]. Previous studies showed that microglia is prominently activated and IL-1 levels increased following MDMA administration [4], lending support to the hypothesis microglia play a role in MDMA induced hyperthermia. Minocycline is a tetracycline antibiotic with powerful anti-inflammatory properties, thought to be a result of its ability to attenuate glial activation [5]. This study examined whether preventing microglial activation through the administration of minocycline could limit or prevent the hyperthermia induced by MDMA.
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