红细胞中的ClC-2通道

Q3 Computer Science

Open Bioinformatics Journal Pub Date : 2011-01-31 DOI:10.2174/1874196701104010018

E. Shumilina, S. Huber

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引用次数: 3

摘要

ClC-2是一种普遍表达的质膜Cl -通道，据报道，它控制着小鼠视网膜和睾丸的离子环境。除此之外，ClC-2可能分别通过其羧基端胱硫氨酸- β合成酶(CBS)结构域和与热休克蛋白Hsp90的分子相互作用来感知细胞能量状态和细胞应激。在成熟的人和小鼠红细胞中，ClC-2可被氧化应激和疟疾感染激活。本文描述了红细胞ClC-2通道在氧化损伤红细胞程序性死亡和疟疾感染红细胞调节性体积减少中的可能功能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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ClC-2 Channels in Erythrocytes

ClC-2 is a ubiquitously expressed plasma membrane Cl - channel that reportedly controls the ionic environment in mouse retina and testis. Beyond that, ClC-2 might sense cellular energy status and cellular stress by its carboxy- terminal cystathionine-beta-synthase (CBS) domains and by its molecular interaction with the heat shock protein Hsp90, respectively. In mature human and mouse erythrocytes, ClC-2 is activated by oxidative stress and by malaria infection. This article describes possible function of erythrocyte ClC-2 channels for the programmed death of oxidatively injured erythrocytes and for the regulatory volume decrease of malaria-infected erythrocytes.

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来源期刊

Open Bioinformatics Journal Computer Science-Computer Science (miscellaneous)

CiteScore

2.40

自引率

0.00%

发文量

期刊介绍： The Open Bioinformatics Journal is an Open Access online journal, which publishes research articles, reviews/mini-reviews, letters, clinical trial studies and guest edited single topic issues in all areas of bioinformatics and computational biology. The coverage includes biomedicine, focusing on large data acquisition, analysis and curation, computational and statistical methods for the modeling and analysis of biological data, and descriptions of new algorithms and databases. The Open Bioinformatics Journal, a peer reviewed journal, is an important and reliable source of current information on the developments in the field. The emphasis will be on publishing quality articles rapidly and freely available worldwide.