利用磷酸腺苷络合物诱导癌细胞凋亡

The open cancer journal Pub Date : 2008-06-12 DOI:10.2174/1874079000802010012

V. Pak

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引用次数: 1

摘要

抗癌“灵丹妙药”应该既有疗效又有特异性。我们使用了一种有效的细胞凋亡诱导剂来诱导细胞凋亡。我们需要一种α -胎儿蛋白来传递肝A细胞凋亡I诱导物，这种蛋白特别针对癌细胞。AFP-AI复合物抑制小鼠肿瘤生长，延长小鼠生存期，并在转移性结直肠癌患者中显示50%的应答率。

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The Use of AFP-Complexes to Induce Apoptosis in Cancer Cells~!2008-03-12~!2008-05-20~!2008-06-12~!

An anticancer "magic bullet" should have both efficacy and specificity parts. We have used an effective Apop- tosis I nducer t o t rigger t he apoptosis. A lpha-fetoprotein w as us ed t o de liver A poptosis I nducers s pecifically t o cancer cells. The AFP-AI complex inhibited tumor growth in mice, enlarged mice life survival and has shown a 50% response in patients with metastatic colorectal cancer.

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The open cancer journal

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