盐酸美金刚及其过渡金属配合物的伏安光谱研究

IF 1.4 Q3 CHEMISTRY, MULTIDISCIPLINARY

Physical Chemistry Research Pub Date : 2022-01-01 DOI:10.22036/PCR.2021.289298.1923

Amrita Natekar, R. Dey

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引用次数: 0

摘要

为了了解盐酸美金刚的电化学行为和评价药物的整体反应，采用循环伏安法进行了电分析。研究了药物浓度等溶液变量和扫描速率等仪器变量。药物中存在的官能团可以与人体内存在的过渡金属离子结合，这些离子被发现比母体药物更有效。本文制备了盐酸美金刚的四种过渡金属配合物，即Fe、Cu、Ni和Co配合物。利用红外光谱和原子吸收光谱对过渡金属配合物进行了表征，并用循环伏安法对其氧化还原性能进行了研究。

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Voltammetric and Spectroscopic Studies of Memantine Hydrochloride and its Transition Metal Complexes

An electroanalytical technique, cyclic voltammetry, has been carried out to understand the electrochemical behavior of Memantine hydrochloride and to evaluate the overall response of the drug. The solution variables such as concentration of the drug and instrumental variables such as scan rate have been studied. Functional groups present in the drug can bind to transitional metal ions present in the human body which are found to be more potent than the parent drug. In the present study, four transitional metal complexes of Memantine hydrochloride viz. Fe, Cu, Ni and Co complexes have been prepared. Characterization of transitional metal complexes is carried out using IR and Atomic Absorption Spectroscopy and the redox properties are investigated using cyclic voltammetry.

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来源期刊

Physical Chemistry Research CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

2.70

自引率

8.30%

发文量

期刊介绍： The motivation for this new journal is the tremendous increasing of useful articles in the field of Physical Chemistry and the related subjects in recent years, and the need of communication between Physical Chemists, Physicists and Biophysicists. We attempt to establish this fruitful communication and quick publication. High quality original papers in English dealing with experimental, theoretical and applied research related to physics and chemistry are welcomed. This journal accepts your report for publication as a regular article, review, and Letter. Review articles discussing specific areas of physical chemistry of current chemical or physical importance are also published. Subjects of Interest: Thermodynamics, Statistical Mechanics, Statistical Thermodynamics, Molecular Spectroscopy, Quantum Chemistry, Computational Chemistry, Physical Chemistry of Life Sciences, Surface Chemistry, Catalysis, Physical Chemistry of Electrochemistry, Kinetics, Nanochemistry and Nanophysics, Liquid Crystals, Ionic Liquid, Photochemistry, Experimental article of Physical chemistry. Mathematical Chemistry.