新化合物LKHT 3-21抗缺氧活性的动物实验研究

Q4 Biochemistry, Genetics and Molecular Biology

Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine Pub Date : 2023-01-01 DOI:10.21687/0233-528x-2023-57-1-82-85

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引用次数: 0

摘要

在不同急性缺氧模型小鼠实验中，新合成的化合物LKhT 3-21 (50 mg/kg)显示出明显的抗缺氧活性。与墨西哥(50 mg/kg)相比，该化合物在密闭室中，在缺氧性缺氧和组织毒性缺氧下分别延长了107%，47%和70%的寿命。lkht3 -21对急性常压缺氧伴高碳酸血症(1.9倍)、急性血氧性缺氧(1.4倍)和急性组织毒性缺氧(1.6倍)的作用均超过墨西诺。

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INVESTIGATIONS OF THE ANTIHYPOXIC ACTIVITY OF NEW COMPOUND LKHT 3-21 IN EXPERIMENTS WITH ANIMALS

In experiments with mice under various models of acute hypoxia a new synthesized compound LKhT 3-21 (50 mg/kg) showed a distinct antihypoxic activity. In comparison to mexicor (50 mg/kg), this compound increased lifespan in a hermetic chamber, under hemic hypoxia and histotoxic hypoxia by 107 %, 47 %, and 70 %, respectively. LKhT 3-21 exceeded mexicor in the effect against acute normobaric hypoxia with hypercapnia (in 1.9 times), acute hemic hypoxia (in 1.4 times) and acute histotoxic hypoxia (in 1.6 times).

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来源期刊

Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)

CiteScore

0.60

自引率

0.00%

发文量