长期分离ϒ-irradiation对小鼠寿命的影响

Q4 Biochemistry, Genetics and Molecular Biology

Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine Pub Date : 2022-01-01 DOI:10.21687/0233-528x-2022-56-4-77-82

T. M. Bychkova, O. Nikitenko, D. Utina, А.А. Ivanov

{"title":"长期分离ϒ-irradiation对小鼠寿命的影响","authors":"T. M. Bychkova, O. Nikitenko, D. Utina, А.А. Ivanov","doi":"10.21687/0233-528x-2022-56-4-77-82","DOIUrl":null,"url":null,"abstract":"The bio-effect of long-term fractionated γ-irradiation with a low total dose was assessed by the criteria of lifespan and death rate in certain life periods. The experiment was made with 40 female ICR (CD-1) mice. Fractionated irradiation of the animals with γ-quants 60Co (50 mGy×33 wks) brought about reduction of the mice mean life by more than 150 days. The total dose of 1.65 Gy is approximate to the admissible career dose limit for cosmonauts. Untimely deaths, in comparison with the control mice, were observed both in the early and terminal periods. Also, body mass of the irradiated animals was increased throughout the follow-up time. The data can be used for evaluation of the risks of tumor and cardiovascular diseases from chronic irradiation of crews during long-term exploration missions.","PeriodicalId":8683,"journal":{"name":"Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"EFFECT OF LONG-TERM FRACTIONATED ϒ-IRRADIATION ON MICE LIFESPAN\",\"authors\":\"T. M. Bychkova, O. Nikitenko, D. Utina, А.А. Ivanov\",\"doi\":\"10.21687/0233-528x-2022-56-4-77-82\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The bio-effect of long-term fractionated γ-irradiation with a low total dose was assessed by the criteria of lifespan and death rate in certain life periods. The experiment was made with 40 female ICR (CD-1) mice. Fractionated irradiation of the animals with γ-quants 60Co (50 mGy×33 wks) brought about reduction of the mice mean life by more than 150 days. The total dose of 1.65 Gy is approximate to the admissible career dose limit for cosmonauts. Untimely deaths, in comparison with the control mice, were observed both in the early and terminal periods. Also, body mass of the irradiated animals was increased throughout the follow-up time. The data can be used for evaluation of the risks of tumor and cardiovascular diseases from chronic irradiation of crews during long-term exploration missions.\",\"PeriodicalId\":8683,\"journal\":{\"name\":\"Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.21687/0233-528x-2022-56-4-77-82\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Biochemistry, Genetics and Molecular Biology\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.21687/0233-528x-2022-56-4-77-82","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}

引用次数: 0

摘要

以寿命和一定生命期死亡率为标准，评价低总剂量长期分段γ辐照的生物效应。以40只雌性ICR (CD-1)小鼠为实验对象。γ-定量剂60Co (50 mGy×33 wks)对小鼠进行分级辐照，使小鼠平均寿命减少150天以上。1.65戈瑞的总剂量近似于宇航员可接受的职业剂量限值。与对照组小鼠相比，在早期和晚期均观察到过早死亡。此外，在整个随访期间，受辐射动物的体重有所增加。这些数据可用于评估长期勘探任务期间机组人员因慢性辐射而患肿瘤和心血管疾病的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

EFFECT OF LONG-TERM FRACTIONATED ϒ-IRRADIATION ON MICE LIFESPAN

The bio-effect of long-term fractionated γ-irradiation with a low total dose was assessed by the criteria of lifespan and death rate in certain life periods. The experiment was made with 40 female ICR (CD-1) mice. Fractionated irradiation of the animals with γ-quants 60Co (50 mGy×33 wks) brought about reduction of the mice mean life by more than 150 days. The total dose of 1.65 Gy is approximate to the admissible career dose limit for cosmonauts. Untimely deaths, in comparison with the control mice, were observed both in the early and terminal periods. Also, body mass of the irradiated animals was increased throughout the follow-up time. The data can be used for evaluation of the risks of tumor and cardiovascular diseases from chronic irradiation of crews during long-term exploration missions.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)

CiteScore

0.60

自引率

0.00%

发文量