Effect of High-Fluoride Dentifrice on the Enamel Demineralization Related in Concern to Microhardness

Objective: to evaluate the effectiveness of high-fluoride dentifrice in decreasing the process of enamel demineralization. Material and Methods: thirty samples of bovine enamel were confectioned, sanded, polished and tested for determining their initial Knoop hardness. The samples were randomly divided into 3 groups: PD – Placebo Dentifrice, CD – Conventional Dentifrice (1450 ppmF) and HFD – High-Fluoride Dentifrice (5000 ppmF). To evaluate the dynamic process of demineralization, each group was subjected to pH cycling with demineralizing and remineralizing solutions. The samples were immersed for 6 and 18 hours respectively in those solutions for 5 days at 98.6oF. The dentifrice corresponding to each group was diluted (1:3) and the samples were treated for 1 minute, twice a day. After cycling, a final microhardness analysis was performed, using ANOVA and Tukey's test (p<0.05). Results: the results showed that the hardness of the final HFD (247.4±39.4) compared to CD (211.9±53.5) showed no statistical difference (p≤0.05). Conclusion: according to the results, it can be suggested that the high concentration of fluoride in dentifrice exhibited superior results in inhibition of enamel demineralization process than conventional dentifrice.