The Utility of Vascular Dysfunction Studies in the Prediction and Prevention of Preeclampsia: A Historical Review

Preeclampsia is a major cause of maternal and perinatal mortality. Although preeclampsia may be caused by several factors, endothelial cell dysfunction has been proposed as the main pathophysiological cause. Dysfunctional endo- thelium in the uteroplacental circulation not only increases peripheral vascular resistance, but also affects generalized vasoconstriction via humoral factors released from the placenta. A standard method for predicting and preventing preeclampsia has yet to be developed; however, the analysis of a combination of biochemical markers, particularly mark- ers related to vascular dysfunction, may enhance our ability to predict and prevent preeclampsia in the near future.