膀胱癌标志物的作用及预后意义(文献复习)

IF 0.1 Q4 ONCOLOGY

Onkourologiya Pub Date : 2021-07-25 DOI:10.17650/17269776-2021-17-2-145-156

L. I. Belyakova, A. N. Shevchenko, A. Sagakyants, E. Filatova

{"title":"膀胱癌标志物的作用及预后意义(文献复习)","authors":"L. I. Belyakova, A. N. Shevchenko, A. Sagakyants, E. Filatova","doi":"10.17650/17269776-2021-17-2-145-156","DOIUrl":null,"url":null,"abstract":"This review article is devoted to the main problems of early diagnostic and prognosis of non-muscle-invasive bladder cancer, which accounts for 75 % of all newly detected cases of bladder cancer according to statistics. Chromosomal disorders that have been detected in urothelial cells can lead to the development of non-muscle-invasive bladder cancer. The review highlights the main problems of existing diagnostic systems for bladder cancer, their disadvantage and limitations of use in practice. Special attention is given to tumor stem cells, which are actively involved in the development of relapses of malignant neoplasms, and, also play an important role in the development of chemo - and radioresistance of tumor cells. Their significance in the diagnosis, detection of disease recurrence and the possibility of using the data obtained to adjustment therapeutic methods of treatment in oncology is one of the main tasks in cancer pathology.","PeriodicalId":42924,"journal":{"name":"Onkourologiya","volume":"1 1","pages":""},"PeriodicalIF":0.1000,"publicationDate":"2021-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"Markers of bladder cancer: their role and prognostic significance (literature review)\",\"authors\":\"L. I. Belyakova, A. N. Shevchenko, A. Sagakyants, E. Filatova\",\"doi\":\"10.17650/17269776-2021-17-2-145-156\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"This review article is devoted to the main problems of early diagnostic and prognosis of non-muscle-invasive bladder cancer, which accounts for 75 % of all newly detected cases of bladder cancer according to statistics. Chromosomal disorders that have been detected in urothelial cells can lead to the development of non-muscle-invasive bladder cancer. The review highlights the main problems of existing diagnostic systems for bladder cancer, their disadvantage and limitations of use in practice. Special attention is given to tumor stem cells, which are actively involved in the development of relapses of malignant neoplasms, and, also play an important role in the development of chemo - and radioresistance of tumor cells. Their significance in the diagnosis, detection of disease recurrence and the possibility of using the data obtained to adjustment therapeutic methods of treatment in oncology is one of the main tasks in cancer pathology.\",\"PeriodicalId\":42924,\"journal\":{\"name\":\"Onkourologiya\",\"volume\":\"1 1\",\"pages\":\"\"},\"PeriodicalIF\":0.1000,\"publicationDate\":\"2021-07-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Onkourologiya\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.17650/17269776-2021-17-2-145-156\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Onkourologiya","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.17650/17269776-2021-17-2-145-156","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ONCOLOGY","Score":null,"Total":0}

引用次数: 2

摘要

本文就非肌肉浸润性膀胱癌早期诊断及预后的主要问题进行综述。据统计，非肌肉浸润性膀胱癌占所有新发现膀胱癌病例的75%。在尿路上皮细胞中检测到的染色体紊乱可导致非肌肉侵袭性膀胱癌的发展。本文综述了现有膀胱癌诊断系统存在的主要问题、缺点和在实际应用中的局限性。肿瘤干细胞积极参与恶性肿瘤复发的发展，并且在肿瘤细胞的化疗和放射耐药的发展中也起着重要作用。它们在诊断、发现疾病复发以及利用所获得的数据调整肿瘤治疗方法方面的意义是肿瘤病理学的主要任务之一。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Markers of bladder cancer: their role and prognostic significance (literature review)

This review article is devoted to the main problems of early diagnostic and prognosis of non-muscle-invasive bladder cancer, which accounts for 75 % of all newly detected cases of bladder cancer according to statistics. Chromosomal disorders that have been detected in urothelial cells can lead to the development of non-muscle-invasive bladder cancer. The review highlights the main problems of existing diagnostic systems for bladder cancer, their disadvantage and limitations of use in practice. Special attention is given to tumor stem cells, which are actively involved in the development of relapses of malignant neoplasms, and, also play an important role in the development of chemo - and radioresistance of tumor cells. Their significance in the diagnosis, detection of disease recurrence and the possibility of using the data obtained to adjustment therapeutic methods of treatment in oncology is one of the main tasks in cancer pathology.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Onkourologiya ONCOLOGY-

CiteScore

0.40

自引率

0.00%

发文量

审稿时长

10 weeks

期刊介绍： The main objective of the journal "Cancer urology" is publishing up-to-date information about scientific clinical researches, diagnostics, treatment of oncologic urological diseases. The aim of the edition is to inform the experts on oncologic urology about achievements in this area, to build understanding of the necessary integrated interdisciplinary approach in therapy, alongside with urologists, combining efforts of doctors of various specialties (cardiologists, pediatricians, chemotherapeutists et al.), to contribute to raising the effectiveness of oncologic patients’ treatment.