未接种疫苗人群中抗sars - cov -2抗体的血清流行动态

Q4 Medicine
V. Gorodin, A. Redko, N. E. Skoblikov, L. Zhukova
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引用次数: 0

摘要

目标。评估未接种疫苗人群中抗sars - cov -2抗体的血清流行率动态。材料和方法。在2020年最后一个季度的两个月内(开始大规模预防冠状病毒感染之前),我们分析了806名未接种疫苗但无临床症状的人的抗sars - cov -2 IgG总水平和病毒中和IgG(抗rbd /S1)水平的动态。第一次检查时,16.0%的参与者发现抗sars - cov -2总IgG阳性,82.6%为阴性,1.4%的结果不确定。在大流行的两个月内,血清流行率上升了23.7%(从16.0%上升到39.7%)。结果不确定的人的比例保持不变(1.4%)。无症状COVID-19患者最初igg阳性,但在两个月内变为阴性的比例为5.4%。一些总抗sars - cov -2 IgG阳性的个体发现有非反应性抗rbd抗体,不能确保冠状病毒的中和(第一次检查为17.8%,第二次检查为10.6%)。关键词:抗体水平动态,非反应性抗rbd SARS-CoV-2抗体,新型冠状病毒感染,COVID-19
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Dynamics of seroprevalence of anti-SARS-CoV-2 antibodies in non-vaccinated people
Objective. To assess the dynamics of seroprevalence of anti-SARS-CoV-2 antibodies in the population of non-vaccinated people. Materials and methods. During two months of the last quarter of 2020 (before the start of mass vaccination against the coronavirus infection), we analyzed the dynamics of the level of total anti-SARS-CoV-2 IgG and level of virus-neutralizing IgG (anti-RBD/S1) in 806 unvaccinated people without clinical signs of the disease Results. Upon first examination, 16.0% of participants were found to have positive total anti-SARS-CoV-2 IgG, while 82.6% were negative and 1.4% had indeterminate result. During two months of the pandemic, seroprevalence increased by 23.7% (from 16.0% to 39.7%). The proportion of people with an indeterminate result remained the same (1.4%). The proportion of patients with asymptomatic COVID-19 who were initially IgG-positive but became negative in two months was 5.4%. Some individuals with positive total anti-SARS-CoV-2 IgG were found to have non-reactive anti-RBD antibodies that did not ensure neutralization of coronavirus (17.8% upon first and 10.6% upon second examination). Key words: dynamics of antibody level, non-reactive anti-RBD SARS-CoV-2 antibodies, new coronavirus infection, COVID-19
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来源期刊
Infektsionnye Bolezni
Infektsionnye Bolezni Medicine-Infectious Diseases
CiteScore
1.30
自引率
0.00%
发文量
15
期刊介绍: The journal publishes original research works, reviews of literature, lectures, methodological recommendations, clinical observations. Main topics: problems of etiology, pathogenesis, clinical manifestations of infectious diseases, new techniques and methods of their diagnosis, prevention and treatment; special attention is paid to the problems of antibacterial and antiviral therapy, the use of immunoglobulins and interferons, and also to intensive therapy of critical states. The journal is in the List of leading scientific journals and periodicals of the Supreme Attestation Committee, where the principal results of doctoral dissertations should be published.
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