鼻内重组干扰素α -2b在医护人员COVID-19应急预防中的作用

Q4 Medicine

Infektsionnye Bolezni Pub Date : 2021-01-01 DOI:10.20953/1729-9225-2021-1-26-32

I. Feldblium, M. Devyatkov, A. Gendler, S. Maltseva, T. M. Repin, V. Nikolenko

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引用次数: 5

摘要

卫生保健工作者是COVID-19感染的主要风险群体之一，应给予优先保护。目标。目的探讨COVID-19在医护人员中的发展动态和流行过程表现，并评价鼻用重组人α -2b干扰素(Grippferon®)在紧急药物辅助下非特异性预防新型冠状病毒感染中的作用。患者和方法。使用流行动态中的官方统计数据检查了彼尔姆卫生保健工作者的COVID-19发病率。采用队列前瞻性研究，对561名医院传染病科医护人员进行了Grippferon®的预防效果评估。结果。在2020年3月9日至2020年12月6日的调查期间，彼尔姆市卫生保健工作者的COVID-19发病率比一般人群高4倍。发现30-59岁的医护人员更容易患上COVID-19。与其他医疗专业人员相比，医生的感染风险最高。在与COVID-19患者有接触的医生和护士中，Grippferon®的预防效果很高。结论。基于重组干扰素α -2b的药物Grippferon®可推荐用于新型冠状病毒感染的紧急预防，以确保COVID-19大流行期间医护人员和患者的流行病学安全。关键词:COVID-19，发病率，医护人员，重组干扰素α -2b, Grippferon，鼻内使用，预防

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The efficacy of intranasal recombinant interferon alpha-2b for emergency prevention of COVID-19 in healthcare workers

Healthcare workers are one of the main risk groups for COVID-19 infection and should be provided priority protection. Objective. To examine the development dynamics and epidemic process manifestations of COVID-19 in healthcare workers as well as to assess the efficacy of intranasal human recombinant interferon alpha-2b (Grippferon®) for emergency medicationassisted nonspecific prevention of novel coronavirus infection. Patients and methods. The incidence of COVID-19 in Perm healthcare workers was examined using official statistical data in the epidemic dynamics. The prophylactic efficacy of Grippferon® was assessed in the analytic cohort prospective study, involving 561 healthcare workers of infectious diseases hospital departments. Results. The incidence rate of COVID-19 among healthcare workers in Perm for the examined period from 09.03.2020 to 06.12.2020 was four times higher, than in the general population. Healthcare workers aged 30–59 years were found to be more likely to develop COVID-19. Physicians had the highest risk of infection compared to other medical professionals. The prophylactic efficacy of Grippferon® was shown to be high in physicians and nurses, who were in contact with COVID-19 patients. Conclusion. Recombinant interferon alpha-2b-based medication Grippferon® can be recommended for emergency prevention of novel coronavirus infection to ensure epidemiological safety of healthcare workers and patients during the COVID-19 pandemic. Key words: COVID-19, incidence rate, healthcare workers, recombinant interferon alpha-2b, Grippferon, intranasal use, prevention

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来源期刊

Infektsionnye Bolezni Medicine-Infectious Diseases

CiteScore

1.30

自引率

0.00%

发文量

期刊介绍： The journal publishes original research works, reviews of literature, lectures, methodological recommendations, clinical observations. Main topics: problems of etiology, pathogenesis, clinical manifestations of infectious diseases, new techniques and methods of their diagnosis, prevention and treatment; special attention is paid to the problems of antibacterial and antiviral therapy, the use of immunoglobulins and interferons, and also to intensive therapy of critical states. The journal is in the List of leading scientific journals and periodicals of the Supreme Attestation Committee, where the principal results of doctoral dissertations should be published.