S. M. Dehghani, M. Anbardar, I. Shahramian, M. Arán, S. Hamzeloo, F. Fazeli, S. Rakhshaninasab, M. Tahani
{"title":"乳糜泻儿童开始无麸质饮食后抗组织转谷氨酰胺酶正常化的持续时间","authors":"S. M. Dehghani, M. Anbardar, I. Shahramian, M. Arán, S. Hamzeloo, F. Fazeli, S. Rakhshaninasab, M. Tahani","doi":"10.20953/1727-5784-2022-6-33-40","DOIUrl":null,"url":null,"abstract":"The aim of the present study was to investigate the time required for the normalization of anti-tissue transglutaminase antibodies IgA (anti-TTG IgA) after starting a gluten-free diet (GFD) in children with celiac disease (CeD). This study included 59 children under 18 years of age with a confirmed diagnosis of CeD referred to Imam Reza Clinic affiliated with Shiraz University of Medical Sciences. All children were divided into two groups, including those with either <180 or >180 U/mL anti-TTG IgA levels. The titer of anti-TTG IgA was checked after the start of GFD. Data analysis was performed using a SPSS software (version 21). The shortest time of anti-TTG IgA normalization was acquired three months after the start of GFD, while the longest time was 30 months. The total average time of normalization was 12.28 ± 6.48 months. The average periods of normalization in patients with baseline anti-TTG IgA titers of <180 and >180 U/mL were 11.30 ± 6.12 and 13.82 ± 6.86 months, respectively (P > 0.05). According to our results, the duration for normalization of anti-TTG IgA levels after GFD initiation was independent of the baseline antibody titer at the time of diagnosis. Key words: normalization time, transglutaminase, gluten-free diet, celiac disease.","PeriodicalId":53444,"journal":{"name":"Voprosy Detskoi Dietologii","volume":"1 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Duration of anti-tissue transglutaminase normalization after starting a gluten-free diet in children with celiac disease\",\"authors\":\"S. M. Dehghani, M. Anbardar, I. Shahramian, M. Arán, S. Hamzeloo, F. Fazeli, S. Rakhshaninasab, M. Tahani\",\"doi\":\"10.20953/1727-5784-2022-6-33-40\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The aim of the present study was to investigate the time required for the normalization of anti-tissue transglutaminase antibodies IgA (anti-TTG IgA) after starting a gluten-free diet (GFD) in children with celiac disease (CeD). This study included 59 children under 18 years of age with a confirmed diagnosis of CeD referred to Imam Reza Clinic affiliated with Shiraz University of Medical Sciences. All children were divided into two groups, including those with either <180 or >180 U/mL anti-TTG IgA levels. The titer of anti-TTG IgA was checked after the start of GFD. Data analysis was performed using a SPSS software (version 21). The shortest time of anti-TTG IgA normalization was acquired three months after the start of GFD, while the longest time was 30 months. The total average time of normalization was 12.28 ± 6.48 months. The average periods of normalization in patients with baseline anti-TTG IgA titers of <180 and >180 U/mL were 11.30 ± 6.12 and 13.82 ± 6.86 months, respectively (P > 0.05). According to our results, the duration for normalization of anti-TTG IgA levels after GFD initiation was independent of the baseline antibody titer at the time of diagnosis. Key words: normalization time, transglutaminase, gluten-free diet, celiac disease.\",\"PeriodicalId\":53444,\"journal\":{\"name\":\"Voprosy Detskoi Dietologii\",\"volume\":\"1 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Voprosy Detskoi Dietologii\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.20953/1727-5784-2022-6-33-40\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Voprosy Detskoi Dietologii","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.20953/1727-5784-2022-6-33-40","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
Duration of anti-tissue transglutaminase normalization after starting a gluten-free diet in children with celiac disease
The aim of the present study was to investigate the time required for the normalization of anti-tissue transglutaminase antibodies IgA (anti-TTG IgA) after starting a gluten-free diet (GFD) in children with celiac disease (CeD). This study included 59 children under 18 years of age with a confirmed diagnosis of CeD referred to Imam Reza Clinic affiliated with Shiraz University of Medical Sciences. All children were divided into two groups, including those with either <180 or >180 U/mL anti-TTG IgA levels. The titer of anti-TTG IgA was checked after the start of GFD. Data analysis was performed using a SPSS software (version 21). The shortest time of anti-TTG IgA normalization was acquired three months after the start of GFD, while the longest time was 30 months. The total average time of normalization was 12.28 ± 6.48 months. The average periods of normalization in patients with baseline anti-TTG IgA titers of <180 and >180 U/mL were 11.30 ± 6.12 and 13.82 ± 6.86 months, respectively (P > 0.05). According to our results, the duration for normalization of anti-TTG IgA levels after GFD initiation was independent of the baseline antibody titer at the time of diagnosis. Key words: normalization time, transglutaminase, gluten-free diet, celiac disease.
期刊介绍:
The scientific journal Voprosy Detskoi Dietologii is included in the Scopus database. Publisher country is RU. The main subject areas of published articles are Food Science, Pediatrics, Perinatology, and Child Health, Nutrition and Dietetics, Клиническая медицина.